ArticleNature communications2018
A defensin-like protein drives cadmium efflux and allocation in rice.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
97 citing papers in PubMed, 1 synthesis or guideline pooled it, 393 citations in OpenAlex.
- Defensins of Grasses: A Systematic Review.Biomolecules · 2020Pooled it
- Integrative genomics resolves rice loci associated with acidic soil-related aluminum, cadmium, and manganese stress responses.Plant cell reports · 2026Article
- Comparative physiological, hormonal, and transcriptional analyses reveal the difference between diploid and autotetraploid rice under cadmium stress.Plant cell reports · 2026Article
- Behind Tolerance and the Cost of Coexistence: The Cd-Mn Interaction in Sunflower Triggers Translocation Reconfiguration, Impacting Productivity and Food Security.Journal of agricultural and food chemistry · 2026Article
- Molecular insights into cadmium transport and micronutrient crosstalk in rice: Towards minimizing grain Cd.Journal of integrative plant biology · 2026Review
- Single-nucleus RNA-seq and ATAC-seq analyses provide molecular insights into cadmium-stress response in alfalfa roots.Horticulture research · 2026Article
- Arbuscular mycorrhizal fungi and phosphate-solubilizing bacteria synergistically enhance growth and cadmium accumulation of hyperaccumulator Sedum plumbizincicola.BMC plant biology · 2026Article
- miR408-5p and miR408-3p cooperatively reduce cadmium uptake and accumulation in rice.PLoS biology · 2026Article
- Metallochaperone protein OsHIPP53 reduces cadmium accumulation in rice (Oryza sativa L.) roots.Plant cell reports · 2026Article
- Melatonin and Grain Legume Crops: Opportunities for Abiotic Stress Tolerance Enhancement and Food Sustainability.Plants (Basel, Switzerland) · 2025Review
- Identification of High- and Low-Cadmium (Cd)-Accumulating Rice Cultivars Using Combined Molecular Markers.Plants (Basel, Switzerland) · 2025Article
- Cadmium Contamination in Asian Rice (Plants (Basel, Switzerland) · 2025Review
- PromoterEco-Environment & Health · 2025Article
- Navigating the genetic basis of cadmium accumulation: a comprehensive analysis of low-cadmium accumulation rice.Molecular breeding : new strategies in plant improvement · 2025Article
- Rice Adaptation to Abiotic Stresses Caused by Soil Inorganic Elements.International journal of molecular sciences · 2025Review
- Geochemical Speciation, Uptake, and Transportation Mechanisms of Arsenic, Cadmium, and Lead in Soil-Rice Systems: Additional Aspects and Challenges.Antioxidants (Basel, Switzerland) · 2025Review
- Barriers and carriers for transition metal homeostasis in plants.Plant communications · 2025Review
- Peptides from plants and microorganisms: a defense strategy for biotic and abiotic stresses.Frontiers in plant science · 2025Review
- Integrating soil bioavailability and plant physiological responses to establish region-specific safety thresholds for cadmium and arsenic in rice cultivated in karst regions.Frontiers in plant science · 2025Article
- Manganese-oxidizingFrontiers in microbiology · 2025Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pollution by heavy metals limits the area of land available for cultivation of food crops. A potential solution to this problem might lie in the molecular breeding of food crops for phytoremediation that accumulate toxic metals in straw while producing safe and nutritious grains. Here, we identify a rice quantitative trait locus we name cadmium (Cd) accumulation in leaf 1 (CAL1), which encodes a defensin-like protein. CAL1 is expressed preferentially in root exodermis and xylem parenchyma cells. We provide evidence that CAL1 acts by chelating Cd in the cytosol and facilitating Cd secretion to extracellular spaces, hence lowering cytosolic Cd concentration while driving long-distance Cd transport via xylem vessels. CAL1 does not appear to affect Cd accumulation in rice grains or the accumulation of other essential metals, thus providing an efficient molecular tool to breed dual-function rice varieties that produce safe grains while remediating paddy soils.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.