ArticleScientific reports2018
Development of a bacterial cellulose-based hydrogel cell carrier containing keratinocytes and fibroblasts for full-thickness wound healing.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 200 citations in OpenAlex.
- Cellulose and its potential applications in skin biology; a comprehensive review.Drug delivery and translational research · 2026Review
- Cellulose-Based Hydrogels for Chronic Wound Healing: Bridging Biomaterial Design and Clinical Unmet Needs.Gels (Basel, Switzerland) · 2026Review
- Cellulose-based nanomaterials: innovations in wound healing and regenerative medicine.Protoplasma · 2026Review
- Antibacterial and Biocompatible Penicillin-Streptomycin Loaded Bacterial Cellulose (BC) Hydrogels for Wound Healing.Gels (Basel, Switzerland) · 2025Article
- Improving Wound Healing with DICER1-Modified Keratinocytes.ACS omega · 2025Article
- Enzyme-loaded bacterial nanocellulose aerogel as a biocleaning material for artwork restoration.Scientific reports · 2025Article
- Physicochemical Characterization of Injectable Genipin-Crosslinked Gelatin-Kelulut Honey Hydrogels for Future Cutaneous Tissue Loss.Polymers · 2025Article
- Current Paradigms and Future Challenges in Harnessing Nanocellulose for Advanced Applications in Tissue Engineering: A Critical State-of-the-Art Review for Biomedicine.International journal of molecular sciences · 2025Review
- Evaluation of a Kenaf Nanocrystalline Cellulose-based Hydrogel Containing Platelet Lysate for Full-thickness Wound Healing.Recent advances in drug delivery and formulation · 2025Article
- Microwave-Assisted Extraction of Cellulose from Aloe Vera Plant Residue and Preparation of Cellulose Nanocrystal-Poly(vinyl alcohol) Hydrogels.Molecules (Basel, Switzerland) · 2024Article
- Natural biopolymer-based hydrogels: an advanced material for diabetic wound healing.Diabetology international · 2024Review
- Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions.Signal transduction and targeted therapy · 2024Review
- Incorporation of Resveratrol-Hydroxypropyl-β-Cyclodextrin Complexes into Hydrogel Formulation for Wound Treatment.Gels (Basel, Switzerland) · 2024Article
- Three-Dimensional Printed Cellulose for Wound Dressing Applications.3D printing and additive manufacturing · 2023Article
- Enhanced Osteogenesis Potential of MG-63 Cells through Sustained Delivery of VEGF via Liposomal Hydrogel.Gels (Basel, Switzerland) · 2023Article
- Bacterial cellulose: A highly versatile nanomaterial.Microbial biotechnology · 2023Article
- [Research advances of natural biomaterials in promoting wound repair].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Review
- Self-Assembly of Nanocellulose Hydrogels Mimicking Bacterial Cellulose for Wound Dressing Applications.Biomacromolecules · 2023Article
- The contribution of immunohistochemistry to the development of hydrogels for skin repair and regeneration.European journal of histochemistry : EJH · 2023Review
- Antimicrobial Formulation of a Bacterial Nanocellulose/Propolis-Containing Photosensitizer for Biomedical Applications.Polymers · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial cellulose (BC)/acrylic acid (AA) hydrogel has successfully been investigated as a wound dressing for partial-thickness burn wound. It is also a promising biomaterial cell carrier because it bears some resemblance to the natural soft tissue. This study assessed its ability to deliver human epidermal keratinocytes (EK) and dermal fibroblasts (DF) for the treatment of full-thickness skin lesions. In vitro studies demonstrated that BC/AA hydrogel had excellent cell attachment, maintained cell viability with limited migration, and allowed cell transfer. In vivo wound closure, histological, immunohistochemistry, and transmission electron microscopy evaluation revealed that hydrogel alone (HA) and hydrogel with cells (HC) accelerated wound healing compared to the untreated controls. Gross appearance and Masson's trichrome staining indicated that HC was better than HA. This study suggests the potential application of BC/AA hydrogel with dual functions, as a cell carrier and wound dressing, to promote full-thickness wound healing.
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Registered trials
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