ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
The Longitudinal Trajectory of Default Mode Network Connectivity in Healthy Older Adults Varies As a Function of Age and Is Associated with Changes in Episodic Memory and Processing Speed.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
134 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Brain functional connectivity in hyperthyroid patients: systematic review.Frontiers in neuroscience · 2024Pooled it
- The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.Psychophysiology · 2023Pooled it
- Functional connectivity changes in cerebral small vessel disease - a systematic review of the resting-state MRI literature.BMC medicine · 2021Pooled it
- Aberrant brain network connectivity in presymptomatic and manifest Huntington's disease: A systematic review.Human brain mapping · 2020Pooled it
- Trial
- Measuring inter-individual differences in stress sensitivity during MR-guided prostate biopsy.Scientific reports · 2021Trial
- Vocal music enhances memory and language recovery after stroke: pooled results from two RCTs.Annals of clinical and translational neurology · 2020Trial
- Posture-Related Regional Homogeneity Abnormalities in Cerebral Small Vessel Disease: A Multi-Position MRI Study.CNS neuroscience & therapeutics · 2026Article
- Genetic frontotemporal degeneration across the lifespan? A critical appraisal of the neurodevelopmental hypothesis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- A local-to-distant shift in dynamic brain connectivity marks early Alzheimer's risk.GeroScience · 2026Article
- The active ingredients: physical activity features linked to healthy brain aging.Alzheimer's research & therapy · 2026Article
- Altered functional connectivity is associated with Repeatable Battery for the Assessment of Neuropsychological Status across the dementia spectrum.Journal of the International Neuropsychological Society : JINS · 2026Article
- Sub-Regional Motor-Somatosensory Connectivity and Lifespan Plasticity in Functional Networks.Neurosciences (Riyadh, Saudi Arabia) · 2026Article
- Structural and functional alterations of posterior cingulate cortex subregions in successful cognitive aging.Frontiers in aging neuroscience · 2026Article
- Plasma vitamin C levels are associated with brain structural networks on MRI: A large cohort study.PloS one · 2026Article
- Plasma proteomics reveals molecular overlap between physical activity and dementia risk.Brain communications · 2026Article
- Practical judgment in aging: examining behavioral vulnerabilities and neurobiological correlates.Frontiers in psychology · 2026Article
- Modelling cognitive outcomes in the UK Biobank: Education, noradrenaline and frontoparietal networks.PloS one · 2026Article
- Pretangle tau pathology accrual in the default mode network during the progression of Alzheimer's disease.Molecular neurodegeneration advances · 2026Article
- Nonlinear Lifespan Trajectories of Memory and Fluid Reasoning: A Longitudinal GAMM Study.Research square · 2025Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
The default mode network (DMN) supports memory functioning and may be sensitive to preclinical Alzheimer's pathology. Little is known, however, about the longitudinal trajectory of this network's intrinsic functional connectivity (FC). In this study, we evaluated longitudinal FC in 111 cognitively normal older human adults (ages 49-87, 46 women/65 men), 92 of whom had at least three task-free fMRI scans (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.