Evidence map›Paper›PMID 29440500›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Adaptive evolution of genomically recoded

Timothy M Wannier, Aditya M Kunjapur, Daniel P Rice, Michael J McDonald, Michael M Desai, George M Church

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. ACS synthetic biology · 2021
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Advances in adaptive laboratory evolution applications forSynthetic and systems biotechnology · 2025
    Review
  8. In Vivo Biosynthesis and Direct Incorporation of Noncanonical Amino Acids into Proteins.Chembiochem : a European journal of chemical biology · 2025
    Review
  9. Article
  10. Review
  11. The design and engineering of synthetic genomes.Nature reviews. Genetics · 2025
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Genomically recodedbioRxiv : the preprint server for biology · 2024
    Article
  18. Review
  19. Article
  20. Convergent genetic adaptation ofFrontiers in molecular biosciences · 2024
    Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Timothy M WannierDepartment of Genetics, Harvard Medical School, Boston, MA 02115; timothy_wannier@hms.harvard.edu kunjapur@alum.mit.edu gchurch@genetics.med.harvard.edu.
Aditya M KunjapurDepartment of Genetics, Harvard Medical School, Boston, MA 02115; timothy_wannier@hms.harvard.edu kunjapur@alum.mit.edu gchurch@genetics.med.harvard.edu.
Daniel P RiceDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138.
Michael J McDonaldDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138.
Michael M DesaiDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138.
George M ChurchDepartment of Genetics, Harvard Medical School, Boston, MA 02115; timothy_wannier@hms.harvard.edu kunjapur@alum.mit.edu gchurch@genetics.med.harvard.edu.ORCID 0000-0003-3535-2076

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Efforts are underway to construct several recoded genomes anticipated to exhibit multivirus resistance, enhanced nonstandard amino acid (nsAA) incorporation, and capability for synthetic biocontainment. Although our laboratory pioneered the first genomically recoded organism (

Indexed as

Biological EvolutionGenetic EngineeringAdaptation, PhysiologicalDNA, BacterialEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialGenome, BacterialMutationDNA, BacterialEscherichia coli Proteinsadaptive evolutiongenetic code expansionnonstandard amino acidsrecoded genomesynthetic biology

Identifiers

PMID29440500
PMCPMC5866557

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.