Evidence map›Paper›PMID 29440474›Full record

ArticleStroke2018

Neuroprotective Effects of MAGL (Monoacylglycerol Lipase) Inhibitors in Experimental Ischemic Stroke.

Sang-Ho Choi, Allison L Arai, Yongshan Mou, Byeongteck Kang, Cecil Chern-Chyi Yen, John Hallenbeck, Afonso C Silva

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
  3. Chemical Probes for Investigating the Endocannabinoid System.Current topics in behavioral neurosciences · 2026
    Review
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  7. Review
  8. Article
  9. Article
  10. Global Metabolomic Profiling Reveals Disrupted Lipid and Amino Acid Metabolism Between the Acute and Chronic Stages of Ischemic Stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Activation of astroglial CB1R mediates cerebral ischemic tolerance induced by electroacupuncture.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sang-Ho ChoiFrom the Cerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging (S.-H.C., A.A., C.C.-C.Y., A.C.S.); National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD (Y.M., J.H.); and College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea (B.K.).
Allison L AraiFrom the Cerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging (S.-H.C., A.A., C.C.-C.Y., A.C.S.); National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD (Y.M., J.H.); and College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea (B.K.).
Yongshan MouFrom the Cerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging (S.-H.C., A.A., C.C.-C.Y., A.C.S.); National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD (Y.M., J.H.); and College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea (B.K.).
Byeongteck KangFrom the Cerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging (S.-H.C., A.A., C.C.-C.Y., A.C.S.); National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD (Y.M., J.H.); and College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea (B.K.).
Cecil Chern-Chyi YenFrom the Cerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging (S.-H.C., A.A., C.C.-C.Y., A.C.S.); National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD (Y.M., J.H.); and College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea (B.K.).
John HallenbeckFrom the Cerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging (S.-H.C., A.A., C.C.-C.Y., A.C.S.); National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD (Y.M., J.H.); and College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea (B.K.).
Afonso C SilvaFrom the Cerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging (S.-H.C., A.A., C.C.-C.Y., A.C.S.); National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD (Y.M., J.H.); and College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea (B.K.). silvaa@ninds.nih.gov.
National Institutes of Health · USNational Institute of Neurological Disorders and Stroke · US

Funding

Investigation of the Modulators of Cerebrovascular CouplingZIANS003012 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SILVA, AFONSO · 2009 to 2019
$15.4M
Investigation of the Modulators of Cerebrovascular CouplingZ01NS003012 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI SILVA, AFONSO · 2005 to 2008
$2.5M
Intramural NIH HHS Z01 NS003012
6 · The paper itself

Abstract

background and purposeMAGL (monoacylglycerol lipase) is an enzyme that hydrolyzes the endocannabinoid 2-arachidonoylglycerol and regulates the production of arachidonic acid and prostaglandins-substances that mediate tissue inflammatory response. Here, we have studied the effects of the selective MAGL inhibitors JZL184 and MJN110 and their underlying molecular mechanisms on 3 different experimental models of focal cerebral ischemia.

methodsSHR (spontaneously hypertensive rats) and normotensive WKY (Wistar Kyoto) rats were subject to an intracortical injection of the potent vasoconstrictor endothelin-1, permanent occlusion of a distal segment of the middle cerebral artery via craniectomy, or transient occlusion of the middle cerebral artery by the intraluminal suture method. JZL184 or MJN110 was administered 60 minutes after focal cerebral ischemia. Infarct volumes, hemispheric swelling, and functional outcomes were assessed between days 1 to 28 by magnetic resonance imaging, histology, and behavioral tests.

resultsPharmacological inhibition of MAGL significantly attenuated infarct volume and hemispheric swelling. MAGL inhibition also ameliorated sensorimotor deficits, suppressed inflammatory response, and decreased the number of degenerating neurons. These beneficial effects of MAGL inhibition were not fully abrogated by selective antagonists of cannabinoid receptors, indicating that the anti-inflammatory effects are caused by inhibition of eicosanoid production rather than by activation of cannabinoid receptors.

conclusionsOur results suggest that MAGL may contribute to the pathophysiology of focal cerebral ischemia and is thus a promising therapeutic target for the treatment of ischemic stroke.

Indexed as

AnimalsBenzodioxolesBrain IschemiaCarbamatesDisease Models, AnimalEnzyme InhibitorsMaleMonoacylglycerol LipasesNeuroprotective AgentsPiperidinesRatsRats, Inbred SHRRats, Inbred WKYStrokeSuccinimidesBenzodioxolesCarbamatesEnzyme InhibitorsJZL 184MJN110Monoacylglycerol LipasesNeuroprotective AgentsPiperidinesSuccinimidesanimalsendocannabinoidneuroprotectionratsstroke

Identifiers

PMID29440474
PMCPMC5829008
OpenAlexW2793942472

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.