ArticleGut2018
Outcome measures in coeliac disease trials: the Tampere recommendations.
Article in Gut, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03462979 (GlPs Improve Practice), which is not on this map. Cited by 49 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
GlPs Improve Practice (GIP) at Home: Effects of Home Gluten Immunogenic Peptide Testing on Children With Celiac Disease
Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- 'What' and 'How' to Measure in Allergy and Clinical Immunology: A Systematic Review of Core Outcome Sets and Outcome Harmonisation Processes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Pooled it
- European Society for the Study of Coeliac Disease (ESsCD) 2025 Updated Guidelines on the Diagnosis and Management of Coeliac Disease in Adults. Part 2: Management, Follow-Up, and Complex Disease Courses.United European gastroenterology journal · 2026Guideline
- Tools Used to Measure the Physical State of Women with Celiac Disease: A Review with a Systematic Approach.International journal of environmental research and public health · 2020Pooled it
- Serum cytokines elevated during gluten-mediated cytokine release in coeliac disease.Clinical and experimental immunology · 2020Trial
- Quality of life in adults with celiac disease in Spain over a decade.Scientific reports · 2026Article
- Bulb biopsies for diagnosing celiac disease in children: A prospective multicenter study using quantitative histomorphometry.Journal of pediatric gastroenterology and nutrition · 2026Observational
- Testing for Faecal Gluten Immunogenic Peptides: Is It Useful to Evaluate Adherence to Gluten-Free Diet?Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Acceptability of veggie bread among Lebanese adults.Frontiers in public health · 2025Article
- A feasibility study using quantitative and interpretable histological analyses of celiac disease for automated cell type and tissue area classification.Scientific reports · 2024Article
- Development of the celiac disease symptom diary version 2.1Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Article
- Evolution in coeliac disease diagnosis and management.JGH open : an open access journal of gastroenterology and hepatology · 2024Review
- Standardizing Randomized Controlled Trials in Celiac Disease: An International Multidisciplinary Appropriateness Study.Gastroenterology · 2024Article
- Characteristics of Children With Inflammatory Bowel Disease and Coexisting Celiac Disease Seropositivity.Journal of pediatric gastroenterology and nutrition · 2022Article
- Article
- Population-based screening for celiac disease reveals that the majority of patients are undiagnosed and improve on a gluten-free diet.Scientific reports · 2022Article
- Review article: Follow-up of coeliac disease.Alimentary pharmacology & therapeutics · 2022Review
- Evaluation of Celiac Disease by Minimally Invasive Biomarkers in a Spanish Pediatric Population.International journal of environmental research and public health · 2022Article
- Validation of the X-ray microtomography in the assessment of duodenal morphometry and surface area in celiac disease.Frontiers in immunology · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveA gluten-free diet is the only treatment option of coeliac disease, but recently an increasing number of trials have begun to explore alternative treatment strategies. We aimed to review the literature on coeliac disease therapeutic trials and issue recommendations for outcome measures.
designBased on a literature review of 10 062 references, we (17 researchers and 2 patient representatives from 10 countries) reviewed the use and suitability of both clinical and non-clinical outcome measures. We then made expert-based recommendations for use of these outcomes in coeliac disease trials and identified areas where research is needed.
resultsWe comment on the use of histology, serology, clinical outcome assessment (including patient-reported outcomes), quality of life and immunological tools including gluten immunogenic peptides for trials in coeliac disease.
conclusionCareful evaluation and reporting of outcome measures will increase transparency and comparability of coeliac disease therapeutic trials, and will benefit patients, healthcare and the pharmaceutical industry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.