ArticleThe Journal of biological chemistry2018
Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19.
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Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 65 citations in OpenAlex.
- Vitamin D3 ameliorates R-loop-induced replication stress and chromosomal instability in MED12-mutant uterine fibroids.Scientific reports · 2026Article
- Molecular pathology of phyllodes tumours of the breast-much more than MED12.Histopathology · 2026Review
- Article
- Vitamin D3 ameliorates R-loop-induced replication stress and chromosomal instability in MED12-mutant uterine fibroids.Research square · 2026Article
- Article
- The Evolving Molecular Landscape of Uterine Mesenchymal Tumors: Diagnostic and Therapeutic Implications.Cancers · 2025Review
- UTERINE FIBROIDS.Physiological reviews · 2025Review
- The Mediator Complex: A Regulatory Hub for Transcriptional Activity of Nuclear Receptors.Cells · 2025Review
- MED12 dysregulation: insights into cancer and therapeutic resistance.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Med12 cooperates with multiple differentiation signals to facilitate efficient lineage transitions in embryonic stem cells.Journal of cell science · 2025Article
- Mediator kinase inhibition drives myometrial stem cell differentiation and the uterine fibroid phenotype through super-enhancer reprogramming.Journal of molecular medicine (Berlin, Germany) · 2025Article
- Differential Expression of Small Non-Coding RNAs in Uterine Leiomyomas.International journal of molecular sciences · 2025Article
- Detection of exon2-MED12 mutations in uterine leiomyomas from Syrian patients.Scientific reports · 2025Article
- Mediator kinase inhibition drives myometrial stem cell differentiation and the uterine fibroid phenotype through super-enhancer reprogramming.Research square · 2024Article
- Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module.Molecular cell · 2024Article
- MED12 and CDK8/19 Modulate Androgen Receptor Activity and Enzalutamide Response in Prostate Cancer.Endocrinology · 2024Article
- The Future of Targeted Therapy for Leiomyosarcoma.Cancers · 2024Review
- The Effect of Race/Ethnicity and MED12 Mutation on the Expression of Long Non-Coding RNAs in Uterine Leiomyoma and Myometrium.International journal of molecular sciences · 2024Article
- Targeting super-enhancer activity for colorectal cancer therapy.American journal of translational research · 2024Review
- MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas.JCI insight · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 2 countries.
Min Ju ParkDepartments of Molecular Medicine, San Antonio, Texas 78229.
Hailian ShenDepartments of Molecular Medicine, San Antonio, Texas 78229.
Jason M SpaethDepartments of Molecular Medicine, San Antonio, Texas 78229.
Jaana H TolvanenGenome-Scale Biology Program and Department of Medical Genetics, Haartman Institute, University of Helsinki, Biomedicum, P.O. Box 63 (Haartmaninkatu 8), Helsinki FIN-00014, Finland.
Courtney FailorObstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229.
Jennifer F KnudtsonObstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229.
Jessica McLaughlinObstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229.
Sunil K HalderDepartment of Obstetrics and Gynecology, Augusta University, Augusta, Georgia 30912.
Qiwei YangDepartment of Obstetrics and Gynecology, Augusta University, Augusta, Georgia 30912.
Serdar E BulunDepartment of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.
Ayman Al-HendyDepartment of Obstetrics and Gynecology, Augusta University, Augusta, Georgia 30912.
Robert S SchenkenObstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229.
Lauri A AaltonenGenome-Scale Biology Program and Department of Medical Genetics, Haartman Institute, University of Helsinki, Biomedicum, P.O. Box 63 (Haartmaninkatu 8), Helsinki FIN-00014, Finland.
Thomas G BoyerDepartments of Molecular Medicine, San Antonio, Texas 78229. Electronic address: boyer@uthscsa.edu.
The University of Texas Health Science Center at San Antonio · USAugusta University · USUniversity of Helsinki · FINorthwestern University · US
Funding
Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5MUterine Leiomyoma Research Center ProgramP01HD057877 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BULUN, SERDAR E. · 2009 to 2019
$12.2MHypovitaminosis D promotes MED12-associated genomic instability in uterine fibroidsR01HD094378 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AL-HENDY, AYMAN, BOYER, THOMAS G · 2018 to 2022
$4.2MMolecular basis of MED12 in the pathogenesis of uterine fibroidsR01HD087417 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI THOMAS G BOYER · 2017 to 2026
$3.4MInstitutional Career Development Core (KL2)KL2TR002646 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI TSEVAT, JOEL · 2018 to 2022
$3.4MNCATS NIH HHS KL2 TR002646NCATS NIH HHS UL1 TR001120NICHD NIH HHS P01 HD057877NICHD NIH HHS R01 HD087417NICHD NIH HHS R01 HD094378
Abstract
Somatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit
Indexed as
ExonsMutationAllosteric RegulationCyclin CCyclin-Dependent Kinase 8Cyclin-Dependent KinasesFemaleHumansLeiomyomaMediator ComplexMyometriumNeoplasm ProteinsCCNC protein, humanCDK19 protein, humanCDK8 protein, humanCyclin CCyclin-Dependent Kinase 8Cyclin-Dependent KinasesMED12 protein, humanMediator ComplexNeoplasm Proteinsallosteric regulationcancerCDK19CDK8cyclin-dependent kinase (CDK)gene transcriptionMED12MediatorRNA polymerase IItranscription coregulatortumoruterine leiomyoma
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.