Evidence map›Paper›PMID 29440392›Full record

ReviewThe Journal of biological chemistry2018

Structure, function, and mechanism of the core circadian clock in cyanobacteria.

Jeffrey A Swan, Susan S Golden, Andy LiWang, Carrie L Partch

Abstract readReview
In one paragraph

Review in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

  1. Review
  2. Impact of E-Cigarette Use on Circadian Proteins and Cardiovascular Risk Markers.Journal of cardiovascular translational research · 2026
    Article
  3. Post-Translational Modifications in Animal Circadian Clocks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Review
  5. Article
  6. Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Review
  9. A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  10. Article
  11. Review
  12. Alternative splicing ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Review
  15. Article
  16. Alternative splicing ofbioRxiv : the preprint server for biology · 2024
    Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jeffrey A SwanFrom the Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064.
Susan S Goldenthe Department of Molecular Biology and.
Andy LiWangCenter for Circadian Biology and Division of Biological Sciences, University of California San Diego, La Jolla, California 92093, and.
Carrie L PartchFrom the Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, cpartch@ucsc.edu.

Funding

Undergraduate Summer Research Experience: Molecular and cellular mechanisms of circadian timekeeping in a prokaryote modelR35GM118290 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDEN, SUSAN S · 2016 to 2025
$6.7M
The Linchpin that Joins the Circadian Oscillator to Clock OutputR01GM107521 · NIGMS · UNIVERSITY OF CALIFORNIA, MERCED · PI LIWANG, ANDY · 2014 to 2021
$2.8M
Atomic resolution analysis of timekeeping by a protein-based circadian clockR01GM121507 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI PARTCH, CARRIE L · 2017 to 2020
$1.8M
NIGMS NIH HHS R01 GM107521NIGMS NIH HHS R01 GM121507NIGMS NIH HHS R35 GM118290
6 · The paper itself

Abstract

Circadian rhythms enable cells and organisms to coordinate their physiology with the cyclic environmental changes that come as a result of Earth's light/dark cycles. Cyanobacteria make use of a post-translational oscillator to maintain circadian rhythms, and this elegant system has become an important model for circadian timekeeping mechanisms. Composed of three proteins, the KaiABC system undergoes an oscillatory biochemical cycle that provides timing cues to achieve a 24-h molecular clock. Together with the input/output proteins SasA, CikA, and RpaA, these six gene products account for the timekeeping, entrainment, and output signaling functions in cyanobacterial circadian rhythms. This Minireview summarizes the current structural, functional and mechanistic insights into the cyanobacterial circadian clock.

Indexed as

Circadian ClocksBacterial ProteinsCircadian Rhythm Signaling Peptides and ProteinsCyanobacteriaGene Expression Regulation, BacterialModels, MolecularPhotoperiodProtein ConformationProtein KinasesSignal TransductionBacterial ProteinsCikA protein, bacteriaCircadian Rhythm Signaling Peptides and ProteinsKaiA protein, cyanobacteriaKaiB protein, cyanobacteriaKaiC protein, cyanobacteriaProtein KinasesATPases associated with diverse cellular activities (AAA)bacterial protein kinasebacterial signal transductioncircadian rhythmcrystallographynuclear magnetic resonance (NMR)

Identifiers

PMID29440392
PMCPMC5892564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.