Evidence map›Paper›PMID 29440382›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Germ-layer commitment and axis formation in sea anemone embryonic cell aggregates.

Anastasia Kirillova, Grigory Genikhovich, Ekaterina Pukhlyakova, Adrien Demilly, Yulia Kraus, Ulrich Technau

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Marine Model Organisms for Mechanobiology Studies.Results and problems in cell differentiation · 2026
    Review
  3. An abundant membrane protein in the NCAM superfamily is required for epithelial organization in sea anemone embryos.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The Multiscale Wisdom of the Body: Collective Intelligence as a Tractable Interface for Next-Generation Biomedicine.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  9. Article
  10. Article
  11. Lateral cell polarization drives organization of epithelia in sea anemone embryos and embryonic cell aggregates.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Chemical factors induce aggregative multicellularity in a close unicellular relative of animals.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. The evolution of gastrulation morphologies.Development (Cambridge, England) · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anastasia KirillovaDepartment for Molecular Evolution and Development, Center of Organismal Systems Biology, Faculty of Life Sciences, University of Vienna, A-1090 Vienna, Austria.
Grigory GenikhovichDepartment for Molecular Evolution and Development, Center of Organismal Systems Biology, Faculty of Life Sciences, University of Vienna, A-1090 Vienna, Austria; grigory.genikhovich@univie.ac.at yulia_kraus@hydrozoa.org ulrich.technau@univie.ac.at.ORCID 0000-0003-4864-7770
Ekaterina PukhlyakovaDepartment for Molecular Evolution and Development, Center of Organismal Systems Biology, Faculty of Life Sciences, University of Vienna, A-1090 Vienna, Austria.
Adrien DemillyDepartment for Molecular Evolution and Development, Center of Organismal Systems Biology, Faculty of Life Sciences, University of Vienna, A-1090 Vienna, Austria.
Yulia KrausDepartment of Evolutionary Biology, Biological Faculty, Moscow State University, 119234 Moscow, Russia; grigory.genikhovich@univie.ac.at yulia_kraus@hydrozoa.org ulrich.technau@univie.ac.at.
Ulrich TechnauDepartment for Molecular Evolution and Development, Center of Organismal Systems Biology, Faculty of Life Sciences, University of Vienna, A-1090 Vienna, Austria; grigory.genikhovich@univie.ac.at yulia_kraus@hydrozoa.org ulrich.technau@univie.ac.at.

Funding

Austrian Science Fund FWF P 22717Austrian Science Fund FWF P 26962
6 · The paper itself

Abstract

Robust morphogenetic events are pivotal for animal embryogenesis. However, comparison of the modes of development of different members of a phylum suggests that the spectrum of developmental trajectories accessible for a species might be far broader than can be concluded from the observation of normal development. Here, by using a combination of microsurgery and transgenic reporter gene expression, we show that, facing a new developmental context, the aggregates of dissociated embryonic cells of the sea anemone

Indexed as

AnimalsBiological EvolutionCell AggregationEctodermEmbryonic DevelopmentGene Expression Regulation, DevelopmentalGerm LayersSea AnemonesSignal TransductionWnt ProteinsWnt Proteinsbody axesembryonic cell aggregatesgerm layersself-organization

Identifiers

PMID29440382
PMCPMC5828576

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.