Evidence map›Paper›PMID 29440362›Full record

ArticleThe Journal of experimental medicine2018

Sustained Id2 regulation of E proteins is required for terminal differentiation of effector CD8

Kyla D Omilusik, Marija S Nadjsombati, Laura A Shaw, Bingfei Yu, J Justin Milner, Ananda W Goldrath

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 87 citations in OpenAlex.

  1. Article
  2. Exhausted CD8Nature immunology · 2026
    Article
  3. Article
  4. Jump-starting the T cell response in established tumors.bioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Atomistic TCR-ligand interactions instruct memory T-cell differentiation.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Engineering resilient CAR T cells for immunosuppressive environment.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  10. Review
  11. Article
  12. Innateness transcriptome gradients characterize mouse T lymphocyte populations.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Article
  13. Article
  14. Id2 epigenetically controls CD8Cellular & molecular immunology · 2024
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kyla D OmilusikDepartment of Biological Sciences, University of California, San Diego, La Jolla, CA.
Marija S NadjsombatiDepartment of Biological Sciences, University of California, San Diego, La Jolla, CA.ORCID 0000-0001-6632-8381
Laura A ShawDepartment of Biological Sciences, University of California, San Diego, La Jolla, CA.
Bingfei YuDepartment of Biological Sciences, University of California, San Diego, La Jolla, CA.ORCID 0000-0001-5550-6701
J Justin MilnerDepartment of Biological Sciences, University of California, San Diego, La Jolla, CA.
Ananda W GoldrathDepartment of Biological Sciences, University of California, San Diego, La Jolla, CA agoldrath@ucsd.edu.ORCID 0000-0002-5900-508X
University of California San Diego · US

Funding

T cell maintenance: molecular mediators of the TCR-derived survival signalR01AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOLDRATH, ANANDA W · 2006 to 2021
$6.1M
T cell maintenance: molecular mediators of T cell differentiation and survivalR37AI067545 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ananda W Goldrath · 2022 to 2026
$3.0M
Transcriptional regulation of immunological memoryF31AG043222 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAW, LAURA · 2013 to 2016
$135k
NIAID NIH HHS R01 AI067545NIAID NIH HHS R37 AI067545NIA NIH HHS F31 AG043222
6 · The paper itself

Abstract

CD8

Indexed as

Cell DifferentiationAnimalsAntigensBasic Helix-Loop-Helix ProteinsCD8-Positive T-LymphocytesGene DeletionInhibitor of Differentiation Protein 2Lectins, C-TypeMice, Inbred C57BLProtein BindingReceptors, ImmunologicAntigensBasic Helix-Loop-Helix ProteinsIdb2 protein, mouseInhibitor of Differentiation Protein 2Klrg1 protein, mouseLectins, C-TypeReceptors, ImmunologicTcf3 protein, mouse

Identifiers

PMID29440362
PMCPMC5839762
OpenAlexW2793603553

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.