Evidence map›Paper›PMID 29440330›Full record

ArticleHypertension (Dallas, Tex. : 1979)2018

Assessment of the fullPIERS Risk Prediction Model in Women With Early-Onset Preeclampsia.

U Vivian Ukah, Beth Payne, Jennifer A Hutcheon, J Mark Ansermino, Wessel Ganzevoort, Shakila Thangaratinam, Laura A Magee, Peter von Dadelszen

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In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Pooled it
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  8. Evaluating the ability of fullPIERS calculator to predict adverse maternal outcomes in pre-eclampsia at Charlotte Maxeke Johannesburg Academic Hospital.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
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  15. Pre-eclampsia.Nature reviews. Disease primers · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

U Vivian UkahFrom the Departments of Obstetrics and Gynaecology (U.V.U., J.A.H.) and Anesthesiology, Pharmacology, and Therapeutics (B.P., J.M.A.), University of British Columbia, Vancouver, Canada; Healthy Starts Theme, BC Children's Hospital Research Institute, Vancouver, Canada (U.V.U., B.P., J.A.H., J.M.A.); Departments of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands (W.G.); Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (S.T.); and School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, United Kingdom (L.A.M., P.v.D.). Vivian.Ukah@cw.bc.ca.
Beth PayneFrom the Departments of Obstetrics and Gynaecology (U.V.U., J.A.H.) and Anesthesiology, Pharmacology, and Therapeutics (B.P., J.M.A.), University of British Columbia, Vancouver, Canada; Healthy Starts Theme, BC Children's Hospital Research Institute, Vancouver, Canada (U.V.U., B.P., J.A.H., J.M.A.); Departments of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands (W.G.); Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (S.T.); and School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, United Kingdom (L.A.M., P.v.D.).
Jennifer A HutcheonFrom the Departments of Obstetrics and Gynaecology (U.V.U., J.A.H.) and Anesthesiology, Pharmacology, and Therapeutics (B.P., J.M.A.), University of British Columbia, Vancouver, Canada; Healthy Starts Theme, BC Children's Hospital Research Institute, Vancouver, Canada (U.V.U., B.P., J.A.H., J.M.A.); Departments of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands (W.G.); Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (S.T.); and School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, United Kingdom (L.A.M., P.v.D.).
J Mark AnserminoFrom the Departments of Obstetrics and Gynaecology (U.V.U., J.A.H.) and Anesthesiology, Pharmacology, and Therapeutics (B.P., J.M.A.), University of British Columbia, Vancouver, Canada; Healthy Starts Theme, BC Children's Hospital Research Institute, Vancouver, Canada (U.V.U., B.P., J.A.H., J.M.A.); Departments of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands (W.G.); Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (S.T.); and School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, United Kingdom (L.A.M., P.v.D.).
Wessel GanzevoortFrom the Departments of Obstetrics and Gynaecology (U.V.U., J.A.H.) and Anesthesiology, Pharmacology, and Therapeutics (B.P., J.M.A.), University of British Columbia, Vancouver, Canada; Healthy Starts Theme, BC Children's Hospital Research Institute, Vancouver, Canada (U.V.U., B.P., J.A.H., J.M.A.); Departments of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands (W.G.); Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (S.T.); and School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, United Kingdom (L.A.M., P.v.D.).
Shakila ThangaratinamFrom the Departments of Obstetrics and Gynaecology (U.V.U., J.A.H.) and Anesthesiology, Pharmacology, and Therapeutics (B.P., J.M.A.), University of British Columbia, Vancouver, Canada; Healthy Starts Theme, BC Children's Hospital Research Institute, Vancouver, Canada (U.V.U., B.P., J.A.H., J.M.A.); Departments of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands (W.G.); Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (S.T.); and School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, United Kingdom (L.A.M., P.v.D.).
Laura A MageeFrom the Departments of Obstetrics and Gynaecology (U.V.U., J.A.H.) and Anesthesiology, Pharmacology, and Therapeutics (B.P., J.M.A.), University of British Columbia, Vancouver, Canada; Healthy Starts Theme, BC Children's Hospital Research Institute, Vancouver, Canada (U.V.U., B.P., J.A.H., J.M.A.); Departments of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands (W.G.); Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (S.T.); and School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, United Kingdom (L.A.M., P.v.D.).
Peter von DadelszenFrom the Departments of Obstetrics and Gynaecology (U.V.U., J.A.H.) and Anesthesiology, Pharmacology, and Therapeutics (B.P., J.M.A.), University of British Columbia, Vancouver, Canada; Healthy Starts Theme, BC Children's Hospital Research Institute, Vancouver, Canada (U.V.U., B.P., J.A.H., J.M.A.); Departments of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands (W.G.); Women's Health Research Unit, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (S.T.); and School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, United Kingdom (L.A.M., P.v.D.).
Amsterdam UMC Location VUmc · NLQueen Mary University of London · GBBritish Columbia Children's Hospital · CA

Funding

CIHR
6 · The paper itself

Abstract

Early-onset preeclampsia is associated with severe maternal and perinatal complications. The fullPIERS model (Preeclampsia Integrated Estimate of Risk) showed both internal and external validities for predicting adverse maternal outcomes within 48 hours for women admitted with preeclampsia at any gestational age. This ability to recognize women at the highest risk of complications earlier could aid in preventing these adverse outcomes through improved management. Because the majority (≈70%) of the women in the model development had late-onset preeclampsia, we assessed the performance of the fullPIERS model in women with early-onset preeclampsia to determine whether it will be useful in this subgroup of women with preeclampsia. Three cohorts of women admitted with early-onset preeclampsia between 2012 and 2016, from tertiary hospitals in Canada, the Netherlands, and United Kingdom, were used. Using the published model equation, the probability of experiencing an adverse maternal outcome was calculated for each woman, and model performance was evaluated based on discrimination, calibration, and stratification. The total data set included 1388 women, with an adverse maternal outcome rate of 7.3% within 48 hours of admission. The model had good discrimination, with an area under the receiver operating characteristic curve of 0.80 (95% confidence interval, 0.75-0.86), and a calibration slope of 0.68. The estimated likelihood ratio at the predicted probability of ≥30% was 23.4 (95% confidence interval, 14.83-36.79), suggesting a strong evidence to rule in adverse maternal outcomes. The fullPIERS model will aid in identifying women admitted with early-onset preeclampsia in similar settings who are at the highest risk of adverse outcomes, thereby allowing timely and effective interventions.

Indexed as

Decision Support TechniquesEarly Medical InterventionGestational AgePre-EclampsiaAdultCanadaFemaleHumansNetherlandsPregnancyPregnancy OutcomePrognosisQuality ImprovementRisk AssessmentRisk FactorsUnited Kingdomcalibrationgestational agepreeclampsiapregnancyprognosis

Identifiers

PMID29440330
PMCPMC5865495
OpenAlexW2801698912

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.