Evidence map›Paper›PMID 29440294›Full record

ArticleMolecular cancer therapeutics2018

Gary Altwerger, Elena Bonazzoli, Stefania Bellone, Tomomi Egawa-Takata, Gulden Menderes, Francesca Pettinella, Anna Bianchi, Francesco Riccio, Jacqueline Feinberg, Luca Zammataro and 15 more

Open access · greenAbstract read
In one paragraph

Article in Molecular cancer therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

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  15. Near-Infrared Fluorescent Agent forFrontiers in oncology · 2021
    Article
  16. Article
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  18. Article
  19. Folate Receptor α-TargetedMolecular pharmaceutics · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 1 institution in 1 country.

Gary AltwergerDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Elena BonazzoliDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Stefania BelloneDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Tomomi Egawa-TakataDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Gulden MenderesDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Francesca PettinellaDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Anna BianchiDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Francesco RiccioDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Jacqueline FeinbergDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Luca ZammataroDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Chanhee HanDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Ghanshyam YadavDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Katherine DuganDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Ashley MorneaultImmunoGen, Inc., Waltham, Massachusetts.
Jose F PonteImmunoGen, Inc., Waltham, Massachusetts.
Natalia BuzaDepartment of Pathology, Yale University School of Medicine, Connecticut.
Pei HuiDepartment of Pathology, Yale University School of Medicine, Connecticut.
Serena WongDepartment of Pathology, Yale University School of Medicine, Connecticut.
Babak LitkouhiDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Elena RatnerDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Dan-Arin SilasiDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Gloria S HuangDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Masoud AzodiDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Peter E SchwartzDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut.
Alessandro D SantinDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Connecticut. alessandro.santin@yale.edu.
ImmunoGen (United States) · US

Funding

Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI DAVID L RIMM · 1985 to 2026
$85.0M
Integrated genomic analysis of racial disparities in endometrial cancerU01CA176067 · NCI · YALE UNIVERSITY · PI SANTIN, ALESSANDRO D · 2014 to 2018
$1.7M
CPE Peptide-Based Nanoparticles for the Diagnosis and Therapy of Chemotherapy ResR01CA154460 · NCI · YALE UNIVERSITY · PI SANTIN, ALESSANDRO D · 2011 to 2015
$1.7M
NCI NIH HHS P30 CA016359NCI NIH HHS R01 CA154460NCI NIH HHS U01 CA176067
6 · The paper itself

Abstract

Grade 3 endometrioid and uterine serous carcinomas (USC) account for the vast majority of endometrial cancer deaths. The purpose of this study was to determine folic acid receptor alpha (FRα) expression in these biologically aggressive (type II) endometrial cancers and evaluate FRα as a targetable receptor for IMGN853 (mirvetuximab soravtansine). The expression of FRα was evaluated by immunohistochemistry (IHC) and flow cytometry in 90 endometrioid and USC samples. The

Indexed as

Xenograft Model Antitumor AssaysAnimalsAntibodies, Monoclonal, HumanizedAntineoplastic Combined Chemotherapy ProtocolsCell Line, TumorCell SurvivalDrug Resistance, NeoplasmEndometrial NeoplasmsFemaleFolate Receptor 1HumansImmunoconjugatesMaytansineMice, SCIDRetrospective StudiesAntibodies, Monoclonal, HumanizedFolate Receptor 1ImmunoconjugatesMaytansinemirvetuximab soravtansine

Identifiers

PMID29440294
PMCPMC5932245
OpenAlexW2789756749

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.