Evidence map›Paper›PMID 29440263›Full record

ArticleGenes & development2018

Mechanical stress regulates insulin sensitivity through integrin-dependent control of insulin receptor localization.

Jung Kim, David Bilder, Thomas P Neufeld

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Cytoophidia coupling adipose architecture and metabolism.Cellular and molecular life sciences : CMLS · 2022
    Article
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  13. Review
  14. On the Fly: Recent Progress on Autophagy and Aging in Drosophila.Frontiers in cell and developmental biology · 2019
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jung KimDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA.
David BilderDepartment of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA.
Thomas P NeufeldDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA.
University of Minnesota · USUniversity of California, Berkeley · US

Funding

Regulation of TOR Signaling and Autophagy in DrosophilaR01GM062509 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI NEUFELD, THOMAS P. · 2001 to 2013
$3.8M
Shaping of simple organ by anisotropic biomechanical forcesR01GM111111 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BILDER, DAVID · 2014 to 2017
$1.2M
NIGMS NIH HHS R01 GM062509NIGMS NIH HHS R01 GM111111
6 · The paper itself

Abstract

Insulin resistance, the failure to activate insulin signaling in the presence of ligand, leads to metabolic diseases, including type 2 diabetes. Physical activity and mechanical stress have been shown to protect against insulin resistance, but the molecular mechanisms remain unclear. Here, we address this relationship in the

Indexed as

Stress, MechanicalAnimalsCell MembraneDrosophila melanogasterDrosophila ProteinsExtracellular MatrixInsulinIntegrin beta ChainsIntegrinsLarvaMovementReceptor, InsulinSignal TransductionTalinTOR Serine-Threonine KinasesDrosophila ProteinsInsulinIntegrin beta ChainsIntegrinsReceptor, InsulinTalinTOR Serine-Threonine KinasesDrosophilainsulin receptor trackinginsulin sensitivityintegrin signalingmechanical stresstarget of rapamycin (TOR)

Identifiers

PMID29440263
PMCPMC5830928
OpenAlexW2786419135

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.