Evidence map›Paper›PMID 29440261›Full record

ArticleGenes & development2018

Dynamic EBF1 occupancy directs sequential epigenetic and transcriptional events in B-cell programming.

Rui Li, Pierre Cauchy, Senthilkumar Ramamoorthy, Sören Boller, Lukas Chavez, Rudolf Grosschedl

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 98 citations in OpenAlex.

  1. Article
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  6. PervasivebioRxiv : the preprint server for biology · 2025
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  20. The aberrant epigenome ofGenome research · 2023
    Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Rui LiDepartment of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Pierre CauchyDepartment of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Senthilkumar RamamoorthyDepartment of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Sören BollerDepartment of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Lukas ChavezDivision of Pediatric Neurooncology, German Cancer Research Center, 69120 Heidelberg, Germany.
Rudolf GrosschedlDepartment of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
Max Planck Institute of Immunobiology and Epigenetics · DEGerman Cancer Research Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

B-cell fate determination requires the action of transcription factors that operate in a regulatory network to activate B-lineage genes and repress lineage-inappropriate genes. However, the dynamics and hierarchy of events in B-cell programming remain obscure. To uncouple the dynamics of transcription factor expression from functional consequences, we generated induction systems in developmentally arrested

Indexed as

Epigenesis, GeneticTranscription, GeneticAnimalsB-LymphocytesCD79 AntigensCell LineageCells, CulturedChromatinDNAMicePAX5 Transcription FactorPromoter Regions, GeneticProto-Oncogene ProteinsProto-Oncogene Protein Spi-1Stem CellsTrans-ActivatorsCD79 AntigensChromatinDNAEbf1 protein, mousePax5 protein, mousePAX5 Transcription FactorProto-Oncogene ProteinsProto-Oncogene Protein Spi-1Trans-ActivatorsTranscription FactorsB-cell programmingchromatinDNA methylationEBF1IRF4Pax5

Identifiers

PMID29440261
PMCPMC5830932
OpenAlexW2785603098

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.