Evidence map›Paper›PMID 29440130›Full record

ArticleEndocrine connections2018

Cardiac magnetic resonance imaging of myocardial mass and fibrosis in primary aldosteronism.

Marianne Aa Grytaas, Kjersti Sellevåg, Hrafnkell B Thordarson, Eystein S Husebye, Kristian Løvås, Terje H Larsen

Abstract read
In one paragraph

Article in Endocrine connections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marianne Aa GrytaasDepartment of Clinical ScienceUniversity of Bergen, Bergen, Norway Marianne.grytaas@helse-bergen.no.
Kjersti SellevågDepartment of Heart DiseaseHaukeland University Hospital, Bergen, Norway.
Hrafnkell B ThordarsonDepartment of Clinical ScienceUniversity of Bergen, Bergen, Norway.
Eystein S HusebyeDepartment of Clinical ScienceUniversity of Bergen, Bergen, Norway.
Kristian LøvåsDepartment of Clinical ScienceUniversity of Bergen, Bergen, Norway.
Terje H LarsenDepartment of Heart DiseaseHaukeland University Hospital, Bergen, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary aldosteronism (PA) is associated with increased cardiovascular morbidity, presumably due to left ventricular (LV) hypertrophy and fibrosis. However, the degree of fibrosis has not been extensively studied. Cardiac magnetic resonance imaging (CMR) contrast enhancement and novel sensitive T1 mapping to estimate increased extracellular volume (ECV) are available to measure the extent of fibrosis.

objectivesTo assess LV mass and fibrosis before and after treatment of PA using CMR with contrast enhancement and T1 mapping.

methodsFifteen patients with newly diagnosed PA (PA1) and 24 age- and sex-matched healthy subjects (HS) were studied by CMR with contrast enhancement. Repeated imaging with a new scanner with T1 mapping was performed in 14 of the PA1 and 20 of the HS median 18 months after specific PA treatment and in additional 16 newly diagnosed PA patients (PA2).

resultsPA1 had higher baseline LV mass index than HS (69 (53-91) vs 51 (40-72) g/m

conclusionSpecific treatment rapidly reduced LV mass in PA. Increased myocardial fibrosis was not found and may not represent a common clinical problem.

Indexed as

cardiac magnetic resonance imagingleft ventricular mass indexmyocardial fibrosisprimary aldosteronismT1 mapping

Identifiers

PMID29440130
PMCPMC5834771

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.