Evidence map›Paper›PMID 29440121›Full record

ArticleCirculation2018

Risk of Dementia in Adults With Congenital Heart Disease: Population-Based Cohort Study.

Carina N Bagge, Victor W Henderson, Henning B Laursen, Kasper Adelborg, Morten Olsen, Nicolas L Madsen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 4 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 96 citations in OpenAlex.

  1. Pooled it
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  17. Biological Age in Congenital Heart Disease-Exploring the Ticking Clock.Journal of cardiovascular development and disease · 2023
    Review
  18. Access to Specialized Care Across the Lifespan in Tetralogy of Fallot.CJC pediatric and congenital heart disease · 2023
    Review
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  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Carina N BaggeDepartments of Clinical Epidemiology (C.N.B., V.W.H., H.B.L., K.A., M.O., N.L.M.) c.n.bagge@gmail.com.
Victor W HendersonDepartments of Clinical Epidemiology (C.N.B., V.W.H., H.B.L., K.A., M.O., N.L.M.).
Henning B LaursenDepartments of Clinical Epidemiology (C.N.B., V.W.H., H.B.L., K.A., M.O., N.L.M.).
Kasper AdelborgDepartments of Clinical Epidemiology (C.N.B., V.W.H., H.B.L., K.A., M.O., N.L.M.).
Morten OlsenDepartments of Clinical Epidemiology (C.N.B., V.W.H., H.B.L., K.A., M.O., N.L.M.).
Nicolas L MadsenDepartments of Clinical Epidemiology (C.N.B., V.W.H., H.B.L., K.A., M.O., N.L.M.).
Aarhus University Hospital · DKCincinnati Children's Hospital Medical Center · US

Funding

Working Memory in Parkinson Disease: A Cognitive & Systems Neuroscience ApproachP50AG047366 · NIA · STANFORD UNIVERSITY · PI HENDERSON, VICTOR · 2015 to 2019
$7.9M
NIA NIH HHS P50 AG047366
6 · The paper itself

Abstract

backgroundMore children with congenital heart disease (CHD) are surviving to adulthood, and CHD is associated with risk factors for dementia. We compared the risk of dementia in CHD adults to that of the general population.

methodsIn this cohort study, we used medical registries and a medical record review covering all Danish hospitals to identify adults with CHD diagnosed between 1963 and 2012. These individuals with CHD were followed from January 1, 1981, 30 years of age, or date of first CHD registration (index date for matched members of the general population cohort) until hospital diagnosis of dementia, death, emigration, or end of study (December 31, 2012). For each individual with CHD, we identified 10 members of the general population utilizing the Danish Civil Registration System matched on sex and birth year. We computed cumulative incidences and hazard ratios (HRs) of dementia, adjusting for sex and birth year.

resultsThe cumulative incidence of dementia was 4% by 80 years of age in 10 632 adults with CHD (46% male). The overall HR comparing adults with CHD with the general population cohort was 1.6 (95% confidence interval [CI], 1.3-2.0). The HR among individuals with CHD without extracardiac defects was 1.4 (95% CI, 1.1-1.8). Adults with mild-to-moderate CHD had an HR of 1.5 (95% CI, 1.1-2.0), whereas the HR was 2.0 (95% CI, 1.2-3.3) for severe CHD, including univentricular hearts. The HR for early onset dementia (<65 years of age) was 2.6 (95% CI, 1.8-3.8), whereas the late-onset HR was 1.3 (95% CI, 1.0-1.8).

conclusionsCHD was associated with an increased risk of dementia compared with the general population, in particular for early onset dementia. Further understanding of dementia risk in the population with CHD is a potential target for future investigation.

Indexed as

SurvivorsAdultAgedAged, 80 and overAge of OnsetDementiaDenmarkFemaleHeart Defects, CongenitalHumansIncidenceMaleMiddle AgedPrognosisRegistriesRisk Assessmentcohort studycongenital heart diseasedementiaepidemiologylong-term outcome

Identifiers

PMID29440121
PMCPMC5930034
OpenAlexW2788289303

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.