ArticleJournal of the American Heart Association2018
U-Shaped Association Between Serum Uric Acid Levels With Cardiovascular and All-Cause Mortality in the Elderly: The Role of Malnourishment.
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 3 of them syntheses that pooled it.
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Who cites it
100 citing papers in PubMed, 3 syntheses or guidelines pooled it, 172 citations in OpenAlex.
- Effect of Uric Acid-Lowering Agents on Patients With Heart Failure: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.Frontiers in cardiovascular medicine · 2021Pooled it
- Impact of Serum Uric Acid Lowering and Contemporary Uric Acid-Lowering Therapies on Cardiovascular Outcomes: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Serum uric acid and risk of cardiovascular mortality: a systematic review and dose-response meta-analysis of cohort studies of over a million participants.BMC cardiovascular disorders · 2019Pooled it
- Trial
- The Nonlinear Relationship Between Serum Uric Acid and Cardiovascular Disease Risk: Mechanistic Insights and Clinical Implications.Cardiovascular drugs and therapy · 2026Review
- Redefining Uric Acid and Cardiovascular Risk: Vascular Gout and Crystal-Driven Vascular Inflammation in Asymptomatic Hyperuricemia.JACC. Asia · 2026Review
- Association of hyperuricemia with valvular heart disease and the modifying effect of obesity.The Korean journal of internal medicine · 2026Article
- Association between TyHGB and hyperuricemia and gout in patients with type-2 diabetes mellitus.BMC endocrine disorders · 2026Article
- Serum Uric Acid Levels in Older Adults: Associations With Clinical Outcomes and Implications for Reference Intervals in Those Aged 70 Years and Over.Arthritis care & research · 2026Article
- J-shaped associations of serum urate with all-cause and cause-specific mortality in diabetes: mediation by kidney function.Acta diabetologica · 2026Article
- Factors influencing serum uric acid levels and their impact on cardiovascular risk in patients with pediatric chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2026Article
- The association of serum uric acid with severity and prognosis of patients with diabetic foot ulcers.Frontiers in endocrinology · 2026Article
- Association between serum vitamin D levels and cardiovascular disease risk in patients with hyperuricemia: A cross-sectional study.PloS one · 2026Article
- Article
- The impact of uric acid on acute coronary syndrome prognosis in elderly patients.Annals of medicine · 2025Article
- Mediating Effect of Serum Uric Acid in the Association Between Nocturia and Mortality.International neurourology journal · 2025Article
- Association between uric acid to albumin ratio and all-cause mortality among United States adults: An observational study.Medicine · 2025Observational
- Serum uric acid and the risk of major adverse cardiovascular events and death among older adults: a population-based prospective cohort study.BMC geriatrics · 2025Article
- Article
- Low Serum Uric Acid as an Independent Predictor of Mortality and Poor Prognosis: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe link between elevated serum uric acid (SUA) levels and cardiovascular disease (CVD)-related mortality in the elderly population remains inconclusive. Nutritional status influences both SUA and CVD outcomes. Therefore, we investigated whether SUA-predicted mortality and the effect-modifying roles of malnourishment in older people. METHODS AND
resultsA longitudinal Taiwanese cohort including 127 771 adults 65 years and older participating in the Taipei City Elderly Health Examination Program from 2001 to 2010 were stratified by 1-mg/dL increment of SUA. Low SUA (<4 mg/dL) strata was categorized by malnourishment status defined as Geriatric Nutritional Risk Index <98, serum albumin <38 g/L, or body mass index <22 kg/m
conclusionsSUA ≥8 or <4 mg/dL independently predicts higher all-cause and CVD-related mortality in the elderly, particularly in those with malnourishment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.