ArticleJournal of the American Heart Association2018
Recommendations to Enhance Pediatric Cardiovascular Drug Development: Report of a Multi-Stakeholder Think Tank.
Abstract readConsensus Statement
In one paragraph
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Methylprednisolone for Heart Surgery in Infants - A Randomized, Controlled Trial.The New England journal of medicine · 2022Trial
- Pediatric heart failure in the era of cardio-immunology: inflammatory-immune context phenotypes, diagnosis, and targeted management.Frontiers in immunology · 2026Review
- Pediatric Heart Failure Pharmacotherapy: Transformative Insights for the Future.Reviews in cardiovascular medicine · 2025Review
- Moving beyond biology: the critical role of social and structural determinants in atopic dermatitis.International journal of dermatology · 2025Review
- Applying Artificial Intelligence in Pediatric Clinical Trials: Potential Impacts and Obstacles.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024Article
- Evaluating registry-based trial economics: Results from the STRESS clinical trial.Contemporary clinical trials communications · 2024Article
- A point-of-care pharmacokinetic/pharmacodynamic trial in critically ill children: Study design and feasibility.Contemporary clinical trials communications · 2023Article
- Kids Mod PAH trial: A multicenter trial comparing mono- versus duo-therapy for initial treatment of pediatric pulmonary hypertension.Pulmonary circulation · 2023Article
- Management of Multisystem Inflammatory Syndrome in Children: Decision-Making Regarding a New Condition in the Absence of Clinical Trial Data.The Canadian journal of cardiology · 2023Review
- Using Pharmacokinetic Modeling and Electronic Health Record Data to Predict Clinical and Safety Outcomes after Methylprednisolone Exposure during Cardiopulmonary Bypass in Neonates.Congenital heart disease · 2023Article
- Preparing newborn screening for the future: a collaborative stakeholder engagement exploring challenges and opportunities to modernizing the newborn screening system.BMC pediatrics · 2022Article
- Important Considerations in Pediatric Heart Failure.Current cardiology reports · 2020Review
- Overcoming underpowering: Trial simulations and a global rank end point to optimize clinical trials in children with heart disease.American heart journal · 2020Article
- Rationale and design of the STeroids to REduce Systemic inflammation after infant heart Surgery (STRESS) trial.American heart journal · 2020Article
- A multi-national trial of a direct oral anticoagulant in children with cardiac disease: Design and rationale of the Safety of ApiXaban On Pediatric Heart disease On the preventioN of Embolism (SAXOPHONE) study.American heart journal · 2019Article
- Treatment of pediatric pulmonary arterial hypertension: A focus on the NO-sGC-cGMP pathway.Pediatric pulmonology · 2019Review
- Pediatric melanoma-The whole (conflicts of interest) story.International journal of women's dermatology · 2019Review
- The Challenges of Pediatric Drug Development.Current therapeutic research, clinical and experimental · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors.
Rachel D TorokDuke University and the Duke Clinical Research Institute, Durham, NC.
Jennifer S LiDuke University and the Duke Clinical Research Institute, Durham, NC.
Prince J KannankerilVanderbilt University Medical Center, Nashville, TN.
Andrew M AtzMedical University of South Carolina, Charleston, SC.
Raafat BishaiAstraZeneca, Gaithersburg, MD.
Ellen BolotinBayer AG, Whippany, NJ.
Stefanie BreitensteinBayer AG, Whippany, NJ.
Cathy ChenDaiichi Sankyo, Parsippany, NJ.
Thomas DiacovoColumbia University Medical Center, New York, NY.
Timothy FeltesNationwide Children's Hospital, Columbus, OH.
Patricia FurlongParent Project Muscular Dystrophy, Middletown, OH.
Michael HannaBristol-Myers Squibb, Princeton, NJ.
Eric M GrahamMedical University of South Carolina, Charleston, SC.
Daphne HsuAlbert Einstein College of Medicine, New York, NY.
D Dunbar IvyChildren's Hospital of Colorado, Aurora, CO.
Dianne MurphyUS Food and Drug Administration , Silver Spring, MD.
Lisa A KammermanAstraZeneca, Gaithersburg, MD.
Gregory KearnsArkansas Children's Hospital, Little Rock, AR.
John LawrenceBristol-Myers Squibb, Princeton, NJ.
Brigitte LebeautDaiichi Sankyo, Parsippany, NJ.
Danshi LiBristol-Myers Squibb, Princeton, NJ.
Christoph MaleMedical University of Vienna, Austria.
Brian McCrindleUniversity of Toronto, Canada.
Pierre MugnierBristol-Myers Squibb, Princeton, NJ.
Jane W NewburgerBoston Children's Hospital, Boston, MA.
Gail D PearsonUS National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
Vasum PeirisUS Food and Drug Administration , Silver Spring, MD.
Lisa PercivalBristol-Myers Squibb, Princeton, NJ.
Miriam PinaJanssen Pharmaceuticals, Raritan, NJ.
Ronald PortmanNovartis Pharmaceuticals, East Hanover, NJ.
Robert ShaddyChildren's Hospital of Los Angeles, CA.
Norman L StockbridgeUS Food and Drug Administration , Silver Spring, MD.
Robert TempleUS Food and Drug Administration , Silver Spring, MD.
Kevin D HillDuke University and the Duke Clinical Research Institute, Durham, NC kevin.hill@duke.edu.
Funding
Neonatal and Pediatric Platelet Function and PharmacologyR01HD081281 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DIACOVO, THOMAS G, DIAMOND, SCOTT L · 2015 to 2019
$2.3MNICHD NIH HHS R01 HD081281
Abstract
PubMed holds no abstract for this paper.
Indexed as
Endpoint DeterminationPatient SelectionAdolescentAge FactorsAntihypertensive AgentsCardiovascular AgentsCardiovascular DiseasesChildChild, PreschoolClinical Trials as TopicConsensusDrug DevelopmentHumansHypolipidemic AgentsInfantInfant, NewbornAntihypertensive AgentsCardiovascular AgentsHypolipidemic Agentsclinical trialdrug developmentoutcomespediatric cardiologyregulation
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.