Evidence map›Paper›PMID 29439979›Full record

ArticleAntimicrobial agents and chemotherapy2018

Prediction Model for Antimalarial Activities of Hemozoin Inhibitors by Using Physicochemical Properties.

Farhana Mosaddeque, Shusaku Mizukami, Mohamed Gomaa Kamel, Awet Alem Teklemichael, Truong Van Dat, Satoshi Mizuta, Dinh Van Toan, Ali Mahmoud Ahmed, Nguyen Lam Vuong, Mohamed Tamer Elhady and 9 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Farhana Mosaddeque *Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan.
Shusaku Mizukami *Department of Clinical Product Development, Institute of Tropical Medicine (NEKKEN), Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Mohamed Gomaa Kamel *Online Research Club‡.
Awet Alem TeklemichaelDepartment of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan.
Truong Van DatUniversity of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Satoshi MizutaCenter for Bioinformatics and Molecular Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Dinh Van ToanUniversity of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Ali Mahmoud AhmedOnline Research Club‡.
Nguyen Lam VuongOnline Research Club‡.
Mohamed Tamer ElhadyOnline Research Club‡.
Hoang Thi Nam GiangOnline Research Club‡.
Tran Ngoc DangOnline Research Club‡.
Michiko FukudaDepartment of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan.
Lam K HuynhInternational University, VNU-HCM, Ho Chi Minh City, Vietnam.
Yoshimasa TanakaCenter for Bioinformatics and Molecular Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Timothy J EganDepartment of Chemistry, University of Cape Town, Rondebosch, South Africa.
Osamu KanekoLeading Program, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Nguyen Tien HuyLeading Program, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan tienhuy@nagasaki-u.ac.jp kenji@nagasaki-u.ac.jp.
Kenji HirayamaDepartment of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan tienhuy@nagasaki-u.ac.jp kenji@nagasaki-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid spread of strains of malaria parasites that are resistant to several drugs has threatened global malaria control. Hence, the aim of this study was to predict the antimalarial activity of chemical compounds that possess anti-hemozoin-formation activity as a new means of antimalarial drug discovery. After the initial

Indexed as

AnimalsAntimalarialsBayes TheoremChloroquineHemeproteinsHumansMalariaMefloquinePlasmodium falciparumAntimalarialsChloroquineHemeproteinshemozoinMefloquineantimalarialdrughemozoinmalariaprediction

Identifiers

PMID29439979
PMCPMC5923155

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.