Evidence map›Paper›PMID 29439960›Full record

ArticleAntimicrobial agents and chemotherapy2018

Anidulafungin Pharmacokinetics in Ascites Fluid and Pleural Effusion of Critically Ill Patients.

R Welte, P Eller, I Lorenz, M Joannidis, R Bellmann

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Candida.JHLT open · 2025
    Article
  3. Limitations of antifungal prophylaxis in preventing invasiveAntimicrobial agents and chemotherapy · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Human Tissue Distribution of Anidulafungin and Micafungin.Antimicrobial agents and chemotherapy · 2021
    Article
  8. Article
  9. Open forum infectious diseases · 2021
    Article
  10. Invasive Fungal Infection After Lung Transplantation: Epidemiology in the Setting of Antifungal Prophylaxis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  11. An Update on Invasive Fungal Infections in Solid Organ Transplant Recipients.Transplant infectious disease : an official journal of the Transplantation Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

R WelteClinical Pharmacokinetics Unit, Division of Intensive Care and Emergency Medicine, Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria.
P EllerDepartment of Internal Medicine, Medical University of Graz, Graz, Austria.
I LorenzGeneral and Surgical ICU, Department of General and Surgical Intensive Care Medicine, Center of Operative Medicine, Medical University of Innsbruck, Innsbruck, Austria.
M JoannidisDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria.
R BellmannClinical Pharmacokinetics Unit, Division of Intensive Care and Emergency Medicine, Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria romuald.bellmann@i-med.ac.at.
Innsbruck Medical University · ATMedical University of Graz · ATUniversität Innsbruck · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anidulafungin concentrations were quantified with high-pressure liquid chromatography (HPLC) and UV detection of the ascites fluid and pleural effusion of 10 adult critically ill patients. Samples were collected from ascites fluid and from pleural drains or during paracentesis and thoracentesis, respectively. Anidulafungin levels in ascites fluid (0.12 to 0.99 μg/ml) and in pleural effusion (0.32 to 2.02 μg/ml) were below the simultaneous levels in plasma (1.04 to 7.70 and 2.48 to 13.36 μg/ml, respectively) and below the MIC values for several pathogenic

Indexed as

AdultAgedAged, 80 and overAnidulafunginAntifungal AgentsAscitesCandidaChromatography, High Pressure LiquidCritical IllnessEchinocandinsFemaleHumansMaleMiddle AgedPleural EffusionAnidulafunginAntifungal AgentsEchinocandinsantifungal target-site pharmacokineticsechinocandinsfungal peritonitisfungal thoracic empyemainvasive candidiasisinvasive fungal diseasetissue distribution

Identifiers

PMID29439960
PMCPMC5913985
OpenAlexW2792522112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.