ArticleMicrobiome2018
Antibiotic-mediated changes in the fecal microbiome of broiler chickens define the incidence of antibiotic resistance genes.
Article in Microbiome, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
100 citing papers in PubMed, 281 citations in OpenAlex.
- Pooled Shotgun Metagenomics Reveals Cloacal Microbiota Composition and Resistome Patterns in Chickens from Kazakhstan.Microorganisms · 2026Article
- Icariin shapes post-withdrawal fecal resistome dynamics in layer hens.Journal of animal science and biotechnology · 2026Article
- Unveiling the presence of ESBL-producing coliform bacteria in the aquaculture system of Cumilla District of Bangladesh.New microbes and new infections · 2026Article
- Resistome flow in global landfill systems.iMetaOmics · 2026Article
- Transcriptome analysis reveals KRAS as a crucial regulator of ovarian follicle development in Wuding chickens.BMC genomics · 2026Article
- Supplemented Feed for Broiler Chickens: The Influence of Red Grape Pomace and Grape Seed Flours on Meat Characteristics.Animals : an open access journal from MDPI · 2026Article
- Coccidiosis prevention strategies shape the microbiome, resistome and mobilome composition in the broiler gut.Animal microbiome · 2026Article
- Multidimensional regulatory mechanisms of chicken immunity: focus on viral infection, intestinal microbiota and heat stress.Frontiers in veterinary science · 2026Review
- Antibiotic-degrading bacteria shape resistome dynamics and horizontal gene transfer potential in soils with contrasting properties.ISME communications · 2026Article
- The fecal resistome of beef cattle from conventional grain-fed and grass-fed systems in the Western United States.BMC microbiology · 2025Article
- Exploring diversity and distribution patterns of chicken gut bacteriophage community.Animal microbiome · 2025Article
- Xenobiotics and Broiler Microbiota: Molecular Insights into Bacterial Antimicrobial Resistance and Food Safety Implications for Human Health.Journal of xenobiotics · 2025Review
- Environmental fate of antibiotic resistance genes in livestock farming.Archives of microbiology · 2025Review
- Distribution of Antimicrobial Resistance and Biofilm Production Genes in the Genomic Sequences ofAntibiotics (Basel, Switzerland) · 2025Article
- In Vitro Insights into Bacteriocin-Mediated Modulation of Chicken Cecal Microbiota.International journal of molecular sciences · 2025Article
- Antimicrobial Residues in Poultry Litter: Assessing the Association of Antimicrobial Persistence with ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Sludge water: a potential pathway for the spread of antibiotic resistance and pathogenic bacteria from hospitals to the environment.Frontiers in microbiology · 2025Article
- Mechanisms in colistin-resistant superbugs transmissible from veterinary, livestock and animal food products to humans.Iranian journal of veterinary research · 2025Review
- Distribution of antibiotic resistance genes and their pathogen hosts in duck farm environments in south-east coastal China.Applied microbiology and biotechnology · 2024Review
- Effect of gum Arabic as natural prebiotic on intestinal ecosystem of post-hatched broiler chicks.Journal of animal science and technology · 2024Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAntimicrobial agents have been widely used in animal farms to prevent and treat animal diseases and to promote growth. Antimicrobial agents may change the bacterial community and enhance the resistome in animal feces. We used metagenome-wide analysis to investigate the changes in bacterial community, variations in antibiotic resistance genes (ARGs), and their bacterial hosts in the feces of broiler chickens over a full-treatment course of chlortetracycline at low and therapeutic dose levels.
resultsThe effects of chlortetracycline on resistome were dependent on the specific ARG subtypes and not simply the overall community-level ARGs. Therapeutic dose of chlortetracycline promoted the abundance of tetracycline resistance genes (tetA and tetW) and inhibited multidrug resistance genes (mdtA, mdtC, mdtK, ompR, and TolC). The therapeutic dose of chlortetracycline led to loss of Proteobacteria mainly due to the decrease of Escherichia/Shigella (from 72 to 58%). Inhibition of Escherichia by chlortetracycline was the primary reason for the decrease of genes resistant to multiple drugs in the therapeutic dose group. The ARG host Bifidobacterium were enriched due to tetW harbored by Bifidobacterium under chlortetracycline treatment. Escherichia was always the major host for multidrug resistance genes, whereas the primary host was changed from Escherichia to Klebsiella for aminoglycoside resistance genes with the treatment of therapeutic dose of chlortetracycline.
conclusionsWe provided the first metagenomic insights into antibiotic-mediated alteration of ARG-harboring bacterial hosts at community-wide level in chicken feces. These results indicated that the changes in the structure of antibiotic-induced feces microbial communities accompany changes in the abundance of bacterial hosts carrying specific ARGs in the feces microbiota. These findings will help to optimize therapeutic schemes for the effective treatment of antibiotic resistant pathogens in poultry farms. Resistome variations in faecal microbiome of chickens exposed to chlortetracycline.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.