Evidence map›Paper›PMID 29439494›Full record

ArticleToxins2018

Listeriolysin O Causes ENaC Dysfunction in Human Airway Epithelial Cells.

Guang Yang, Helena Pillich, Richard White, Istvan Czikora, Isabelle Pochic, Qiang Yue, Martina Hudel, Boris Gorshkov, Alexander Verin, Supriya Sridhar and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. The Epithelial Sodium Channel-An Underestimated Drug Target.International journal of molecular sciences · 2023
    Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Guang YangVascular Biology Center, Medical College of Georgia at Augusta University, Room CB-3213B, Augusta, GA 30912-2500, USA. guyang@llu.edu.
Helena PillichInstitute of Medical Microbiology, Justus-Liebig University Giessen, 35392 Gießen, Germany. helena.pillich@mikrobio.med.uni-giessen.de.
Richard WhiteDepartment of Pharmacology and Toxicology, Medical College of Georgia at Augusta University, Room CB-3213B, Augusta, GA 30912-2500, USA. richardwhit@pcom.edu.
Istvan CzikoraVascular Biology Center, Medical College of Georgia at Augusta University, Room CB-3213B, Augusta, GA 30912-2500, USA. ICZIKORA@augusta.edu.ORCID 0000-0002-8247-9494
Isabelle PochicBiochemical Pharmacology, University of Konstanz, 78464 Konstanz, Germany. isabelle.pochic@gmx.de.
Qiang YueDepartment of Physiology, Emory School of Medicine, Atlanta, GA 30307, USA. qiang.yue@emory.edu.
Martina HudelInstitute of Medical Microbiology, Justus-Liebig University Giessen, 35392 Gießen, Germany. martina.hudel@mikrobio.med.uni-giessen.de.
Boris GorshkovVascular Biology Center, Medical College of Georgia at Augusta University, Room CB-3213B, Augusta, GA 30912-2500, USA. BGORSHKOV@augusta.edu.
Alexander VerinVascular Biology Center, Medical College of Georgia at Augusta University, Room CB-3213B, Augusta, GA 30912-2500, USA. AVERIN@augusta.edu.
Supriya SridharVascular Biology Center, Medical College of Georgia at Augusta University, Room CB-3213B, Augusta, GA 30912-2500, USA. SUSRIDHAR@augusta.edu.
Carlos M IsalesDepartment of Medicine, Medical College of Georgia, Augusta, GA 30901, USA. CISALES@augusta.edu.
Douglas C EatonDepartment of Physiology, Emory School of Medicine, Atlanta, GA 30307, USA. deaton@emory.edu.
Jürg HamacherBiochemical Pharmacology, University of Konstanz, 78464 Konstanz, Germany. jhamache@hin.ch.
Trinad ChakrabortyInstitute of Medical Microbiology, Justus-Liebig University Giessen, 35392 Gießen, Germany. trinad.chakraborty@mikrobio.med.uni-giessen.de.
Rudolf LucasVascular Biology Center, Medical College of Georgia at Augusta University, Room CB-3213B, Augusta, GA 30912-2500, USA. rlucas@augusta.edu.
Augusta University · USJustus-Liebig-Universität Gießen · DEEmory University · USUniversity of Konstanz · DEPhiladelphia College of Osteopathic Medicine · US

Funding

Therapeutic Mechanisms of RhoA Inhibition In Acute Lung InjuryP01HL101902 · NHLBI · AUGUSTA UNIVERSITY · PI BLACK, STEPHEN M · 2011 to 2016
$11.2M
NHLBI NIH HHS P01 HL101902
6 · The paper itself

Abstract

Pulmonary permeability edema is characterized by reduced alveolar Na⁺ uptake capacity and capillary barrier dysfunction and is a potentially lethal complication of listeriosis. Apical Na⁺ uptake is mainly mediated by the epithelial sodium channel (ENaC) and initiates alveolar liquid clearance. Here we examine how listeriolysin O (LLO), the pore-forming toxin of

Indexed as

AnimalsBacterial ToxinsBronchiCell LineEpithelial CellsEpithelial Sodium ChannelsHeat-Shock ProteinsHemolysin ProteinsHumansImmediate-Early ProteinsMaleMice, Inbred C57BLPeptidesPhosphorylationProtein Kinase C-alphaProtein Serine-Threonine KinasesAKT1 protein, humanBacterial ToxinsEpithelial Sodium ChannelsHeat-Shock ProteinsHemolysin ProteinshlyA protein, Listeria monocytogenesImmediate-Early ProteinspepBs1-Ac peptidePeptidesPRKCA protein, humanProtein Kinase C-alphaProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktSerum-Glucocorticoid Regulated Kinasesepithelial sodium channellisteriolysin Oprotein kinase C-αpulmonary permeability edemaTNF

Identifiers

PMID29439494
PMCPMC5848180
OpenAlexW2793571878

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.