ReviewInternational journal of molecular sciences2018
The Low-Renin Hypertension Phenotype: Genetics and the Role of the Mineralocorticoid Receptor.
Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed.
- Low-renin hypertension in incidental adrenal adenomas and response to aldosterone-targeted therapy: a prospective study.European journal of internal medicine · 2026Article
- Renin-Guided Risk Stratification and Therapy in Hypertension to Reduce Major Adverse Cardiovascular Outcomes.medRxiv : the preprint server for health sciences · 2026Article
- Driving hypertension: non-classic apparent mineralocorticoid excess.Nature reviews. Endocrinology · 2026Article
- ACE Inhibition to Distinguish Low-Renin Hypertension From Primary Aldosteronism.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Licorice Toxicity Presenting As Refractory Hypokalemia and Hypertension in an Elderly Patient.Cureus · 2024Article
- The Spectrum of Dysregulated Aldosterone Production: An International Human Physiology Study.The Journal of clinical endocrinology and metabolism · 2024Article
- Prevalence and Characteristics of Low-renin Hypertension in a Primary Care Population.Journal of the Endocrine Society · 2024Article
- Low Cortisone as a Novel Predictor of the Low-Renin Phenotype.Journal of the Endocrine Society · 2024Article
- Reassessing the management of hypertension: Time to prevent aldosterone-mediated heart failure.European journal of heart failure · 2024Article
- Sex-specific association of low-renin hypertension with metabolic and musculoskeletal health in Korean older adults.Frontiers in public health · 2024Article
- Shifting paradigms in primary aldosteronism: reconsideration of screening strategy via integrating pathophysiological insights.Frontiers in endocrinology · 2024Review
- Diagnosis and Treatment of Monogenic Hypertension in Children.Yonsei medical journal · 2023Review
- Novel metabolomic profile of subjects with non-classic apparent mineralocorticoid excess.Scientific reports · 2021Article
- Association of Serum Aldosterone and Plasma Renin Activity With Ambulatory Blood Pressure in African Americans: The Jackson Heart Study.Circulation · 2021Article
- Detection of Urinary Exosomal HSD11B2 mRNA Expression: A Useful Novel Tool for the Diagnostic Approach of Dysfunctional 11β-HSD2-Related Hypertension.Frontiers in endocrinology · 2021Observational
- Article
- Mild primary aldosteronism (PA) followed by overt PA are possibly the most common forms of low renin hypertension: a single-center retrospective study.Journal of human hypertension · 2020Article
- Lysine-Specific Demethylase-1 Deficiency Increases Agonist Signaling Via the Mineralocorticoid Receptor.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Experimental Rodent Models of Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2020Review
- A rare cause of hypertension in childhood: Answers.Pediatric nephrology (Berlin, Germany) · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A substantial proportion of patients with hypertension have a low or suppressed renin. This phenotype of low-renin hypertension (LRH) may be the manifestation of inherited genetic syndromes, acquired somatic mutations, or environmental exposures. Activation of the mineralocorticoid receptor is a common final mechanism for the development of LRH. Classically, the individual causes of LRH have been considered to be rare diseases; however, recent advances suggest that there are milder and "non-classical" variants of many LRH-inducing conditions. In this regard, our understanding of the underlying genetics and mechanisms accounting for LRH, and therefore, potentially the pathogenesis of a large subset of essential hypertension, is evolving. This review will discuss the potential causes of LRH, with a focus on implicated genetic mechanisms, the expanding recognition of non-classical variants of conditions that induce LRH, and the role of the mineralocorticoid receptor in determining this phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.