ReviewNutrients2018
Zinc and Skin Disorders.
Review in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 3 syntheses or guidelines pooled it, 211 citations in OpenAlex.
- Acrodermatitis enteropathica in the pediatric population: a literature review of real-world studies.Frontiers in nutrition · 2025Pooled it
- The Nutrient-Skin Connection: Diagnosing Eating Disorders Through Dermatologic Signs.Nutrients · 2024Pooled it
- Pooled it
- Prevalence of Zinc Deficiency in Healthy 1-3-Year-Old Children from Three Western European Countries.Nutrients · 2021Trial
- The Zinc-Senescence Axis in Skin Aging and Wound Healing: A Narrative Review.International journal of molecular sciences · 2026Review
- The Evaluation of Zinc Source and Dose in Broiler Diets Fed at Different Calcium and Phosphorus Levels in the Presence or Absence of Phytase.Animals : an open access journal from MDPI · 2026Article
- Skin Thickness Over Cardiac Implantable Electronic Devices: Prognostic Impact and Longitudinal Changes.Pacing and clinical electrophysiology : PACE · 2026Article
- Relationship Between Hemoglobin, Serum Iron, Iron-Binding Capacity, Ferritin, Zinc, Vitamin B12, and Vitamin D Levels in Patients with Melasma and the Severity of Their Condition.The Eurasian journal of medicine · 2026Article
- Nail Amino Acid and Trace Element Profiles and Their Association with Clinical Severity in Nail Psoriasis.Clinical, cosmetic and investigational dermatology · 2026Article
- Heterozygous Variants of the SLC39A4 Gene and Possible Increased Risk for Developing Acrodermatitis Enteropathica with Kaposi's Varicelliform Eruption.The American journal of case reports · 2025Article
- Effect of Supplemental Trace Mineral Source on Haircoat and Hair Loss in Adult Cats.Animals : an open access journal from MDPI · 2025Article
- The Role of Oxidative Stress in Skin Disorders Associated with Alcohol Dependency and Antioxidant Therapies.Molecules (Basel, Switzerland) · 2025Review
- Plasma Zinc Levels in Patients with Diabetic Nephropathy: Is there a Relationship with NLRP3 Inflammasome Activation and Renal Prognosis?Biological trace element research · 2025Article
- A case of acquired acrodermatitis enteropathica in a 91-year-old man.SAGE open medical case reports · 2025Article
- Research progress on the role of fascia in skin wound healing.Burns & trauma · 2025Review
- An Agonist of Zinc-Sensing G-Protein Coupled Receptor 39 Accelerates Skin Wound Healing and Protects Against UVB-Induced Keratinocyte Damage.Journal of experimental pharmacology · 2025Article
- Minerals and Trace Elements: Key Protectors of Skin Health and Defenders against Skin Disorders.Current medicinal chemistry · 2025Review
- Mammalian SLC39A13 promotes ER/Golgi iron transport and iron homeostasis in multiple compartments.Nature communications · 2024Article
- Review
- Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The skin is the third most zinc (Zn)-abundant tissue in the body. The skin consists of the epidermis, dermis, and subcutaneous tissue, and each fraction is composed of various types of cells. Firstly, we review the physiological functions of Zn and Zn transporters in these cells. Several human disorders accompanied with skin manifestations are caused by mutations or dysregulation in Zn transporters; acrodermatitis enteropathica (Zrt-, Irt-like protein (ZIP)4 in the intestinal epithelium and possibly epidermal basal keratinocytes), the spondylocheiro dysplastic form of Ehlers-Danlos syndrome (ZIP13 in the dermal fibroblasts), transient neonatal Zn deficiency (Zn transporter (ZnT)2 in the secretory vesicles of mammary glands), and epidermodysplasia verruciformis (ZnT1 in the epidermal keratinocytes). Additionally, acquired Zn deficiency is deeply involved in the development of some diseases related to nutritional deficiencies (acquired acrodermatitis enteropathica, necrolytic migratory erythema, pellagra, and biotin deficiency), alopecia, and delayed wound healing. Therefore, it is important to associate the existence of mutations or dysregulation in Zn transporters and Zn deficiency with skin manifestations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.