Evidence map›Paper›PMID 29439466›Full record

ArticleInternational journal of molecular sciences2018

Analysis of Peptide Ligand Specificity of Different Insect Adipokinetic Hormone Receptors.

Elisabeth Marchal, Sam Schellens, Emilie Monjon, Evert Bruyninckx, Heather G Marco, Gerd Gäde, Jozef Vanden Broeck, Heleen Verlinden

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 52 citations in OpenAlex.

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  8. Article
  9. Review
  10. Insects as a New Complex Model in Hormonal Basis of Obesity.International journal of molecular sciences · 2021
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Peptide Hormones in the Insect Midgut.Frontiers in physiology · 2020
    Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Elisabeth MarchalMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59, P.O. Box 02465, B-3000 Leuven, Belgium. elisabeth.marchal@kuleuven.be.
Sam SchellensMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59, P.O. Box 02465, B-3000 Leuven, Belgium. sam.schellens@student.kuleuven.be.
Emilie MonjonMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59, P.O. Box 02465, B-3000 Leuven, Belgium. emilie.monjon@kuleuven.be.
Evert BruyninckxMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59, P.O. Box 02465, B-3000 Leuven, Belgium. evert.bruyninckx@kuleuven.be.
Heather G MarcoDepartment of Biological Sciences, University of Cape Town, Private Bag, Rondebosch ZA-7700, South Africa. heather.marco@uct.ac.za.
Gerd GädeDepartment of Biological Sciences, University of Cape Town, Private Bag, Rondebosch ZA-7700, South Africa. gerd.gade@uct.ac.za.
Jozef Vanden BroeckMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59, P.O. Box 02465, B-3000 Leuven, Belgium. jozef.vandenbroeck@kuleuven.be.ORCID 0000-0001-7653-0516
Heleen VerlindenMolecular Developmental Physiology and Signal Transduction, KU Leuven, Naamsestraat 59, P.O. Box 02465, B-3000 Leuven, Belgium. heleen.verlinden@kuleuven.be.
KU Leuven · BEUniversity of Cape Town · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipokinetic hormone (AKH) is a highly researched insect neuropeptide that induces the mobilization of carbohydrates and lipids from the fat body at times of high physical activity, such as flight and locomotion. As a naturally occurring ligand, AKH has undergone quite a number of amino acid changes throughout evolution, and in some insect species multiple AKHs are present. AKH acts by binding to a rhodopsin-like G protein-coupled receptor, which is related to the vertebrate gonadotropin-releasing hormone receptors. In the current study, we have cloned AKH receptors (AKHRs) from seven different species, covering a wide phylogenetic range of insect orders: the fruit fly,

Indexed as

AnimalsCHO CellsCricetinaeCricetulusEvolution, MolecularInsectaInsect HormonesInsect ProteinsOligopeptidesProtein BindingPyrrolidonecarboxylic AcidReceptors, PeptideSubstrate Specificityadipokinetic hormoneInsect HormonesInsect ProteinsOligopeptidesPyrrolidonecarboxylic AcidReceptors, PeptideAKHcarbohydrateenergyGPCRlipidmetabolismneuropeptidepest control

Identifiers

PMID29439466
PMCPMC5855764
OpenAlexW2792438924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.