Trial reportNutrients2018
Effectiveness and Safety of a Probiotic-Mixture for the Treatment of Infantile Colic: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial with Fecal Real-Time PCR and NMR-Based Metabolomics Analysis.
Trial report in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01869426 (Impact of VSL#3 on Infants Colics as Assessed by Average Crying Time), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of VSL#3 on Infants Colics as Assessed by Average Crying Time
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Probiotic Supplementation During the Perinatal and Infant Period: Effects on Gut Dysbiosis and Disease.Nutrients · 2020Pooled it
- Trial
- Human milk and infant formula influence lactobacilli metabolism in a species-specific manner.NPJ science of food · 2026Article
- Functional Significance of Probiotic Bacterial Interactions with Milk Fat Globules in a Human Host.Microorganisms · 2025Review
- The Impact of Bioactive Molecules from Probiotics on Child Health: A Comprehensive Review.Nutrients · 2024Review
- A Mini Literature Review of Probiotics: Transforming Gastrointestinal Health Through Evidence-Based Insights.Cureus · 2024Review
- Probiotics in Functional Gastrointestinal Disorders.Advances in experimental medicine and biology · 2024Review
- Exploring the Effects of Probiotic Treatment on Urinary and Serum Metabolic Profiles in Healthy Individuals.Journal of proteome research · 2023Article
- Probiotics added to maternal nutrition affect ınfantile colic symptoms and fecal microbiota profile: a single-blind randomized controlled study.Clinical and experimental pediatrics · 2022Article
- Review
- Probiotics and Functional Gastrointestinal Disorders in Pediatric Age: A Narrative Review.Frontiers in pediatrics · 2022Review
- Efficacy and Safety of a Colic Relief Remedy in Infantile Colic.Global pediatric health · 2022Article
- Efficacy of probiotics for managing infantile colic due to their anti-inflammatory properties: a meta-analysis and systematic review.Clinical and experimental pediatrics · 2021Article
- Comparison of Publication of Pediatric Probiotic vs Antibiotic Trials Registered on ClinicalTrials.gov.JAMA network open · 2021Review
- Article
- Article
- Metabolomics Applications in Children: A Right Way to Go.Metabolites · 2020Article
- Effects of Vitamin B2 Supplementation in Broilers Microbiota and Metabolome.Microorganisms · 2020Article
- Birth Weight and the Development of Functional Gastrointestinal Disorders in Infants.Pediatric gastroenterology, hepatology & nutrition · 2020Article
- The Effect of Probiotics on Symptoms, Gut Microbiota and Inflammatory Markers in Infantile Colic: A Systematic Review, Meta-Analysis and Meta-Regression of Randomized Controlled Trials.Journal of clinical medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo investigate the effectiveness and the safety of a probiotic-mixture (Vivomixx
methodsA randomized, double-blind, placebo-controlled trial was conducted in exclusively breastfed infants with colic, randomly assigned to receive a probiotic-mixture or a placebo for 21 days. A structured diary of gastrointestinal events of the infants was given to the parents to complete. Samples of feces were also collected to evaluate microbial content and metabolome using fecal real-time polymerase chain reaction (qPCR) and Nuclear magnetic resonance (NMR)-based analysis. Study registered at ClinicalTrials.gov (NCT01869426).
resultsFifty-three exclusively-breastfed infants completed three weeks of treatment with a probiotic-mixture (
conclusionsAdministration of a probiotic-mixture appears safe and reduces inconsolable crying in exclusively breastfed infants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.