ArticleAJNR. American journal of neuroradiology2018
Improved Visualization of Cortical Lesions in Multiple Sclerosis Using 7T MP2RAGE.
Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Imaging cortical multiple sclerosis lesions with ultra-high field MRI.NeuroImage. Clinical · 2021Pooled it
- Multicenter Assessment of Combined Brain and Cervical Spinal cord 3T MP2RAGE T1 Measurements for Reliable Tissue Microstructure Quantification.NMR in biomedicine · 2026Trial
- Quantifying cortical lesions in multiple sclerosis MRI datasets using multi-contrast post-processing and deep learning.Communications medicine · 2026Article
- Whole-brain in situ postmortem MR imaging using a combination of sequences for cortical lesion detection in multiple sclerosis.La Radiologia medica · 2026Article
- Cortical Lesions Form Predominantly in Early Multiple Sclerosis.medRxiv : the preprint server for health sciences · 2026Article
- A comparative study of deep learning for cortical lesion MRI segmentation with explainability analysis in multiple sclerosis.NeuroImage. Clinical · 2026Article
- Evaluation of cortical pathology in primary-progressive multiple sclerosis: a post hoc analysis of the SPRINT-MS trial.BMJ neurology open · 2026Article
- FCRL5, a B-Cell Marker With Novel Diagnostic and Prognostic Value for Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Quantitative T1 is sensitive to cortical remyelination in multiple sclerosis: A postmortem MRI study.Brain pathology (Zurich, Switzerland) · 2025Article
- 7 Tesla MRI in Multiple Sclerosis: Insights From Its Use in Clinical Routine.European journal of neurology · 2025Article
- Benchmarking and Explaining Deep Learning Cortical Lesion MRI Segmentation in Multiple Sclerosis.ArXiv · 2025Article
- Biomarkers of Progression Independent of Relapse Activity-Can We Actually Measure It Yet?International journal of molecular sciences · 2025Review
- Cortical lesions are common in a longitudinal progressive multifocal leukoencephalopathy cohort.Brain communications · 2025Article
- Pooled analysis of multiple sclerosis findings on multisite 7 Tesla MRI: Protocol and initial observations.Human brain mapping · 2024Article
- New Imaging Markers in Multiple Sclerosis and Related Disorders: Smoldering Inflammation and the Central Vein Sign.Neuroimaging clinics of North America · 2024Review
- Decoding Gray Matter Involvement in Multiple Sclerosis via Imaging.Neuroimaging clinics of North America · 2024Review
- Advanced MRI Techniques: Diagnosis and Follow-Up of Multiple Sclerosis.Diagnostics (Basel, Switzerland) · 2024Review
- Contribution of new and chronic cortical lesions to disability accrual in multiple sclerosis.Brain communications · 2024Article
- The use of 7T MRI in multiple sclerosis: review and consensus statement from the North American Imaging in Multiple Sclerosis Cooperative.Brain communications · 2024Review
- Cortical lesions uniquely predict motor disability accrual and form rarely in the absence of new white matter lesions in multiple sclerosis.medRxiv : the preprint server for health sciences · 2023Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 5 countries.
Funding
Abstract
background and purposeCortical lesions are common and often extensive in multiple sclerosis but are difficult to visualize by MRI, leaving important questions about their clinical implications and response to therapy unanswered. Our aim was to determine whether cortical lesions are better visualized using magnetization prepared 2 rapid acquisition gradient echoes (MP2RAGE) than T2*-weighted imaging on 7T MR imaging. MATERIALS AND
methodsBrain MR imaging using T1-weighted MP2RAGE at 500-μm isotropic resolution, T2*-weighted gradient-echo, and T2*-weighted segmented echo-planar imaging sequences were collected for 13 patients with MS and 5 age-matched neurologically healthy controls on a 7T research system. One MS case underwent postmortem MR imaging including gradient-echo and MP2RAGE sequences, after which cortical lesions seen on MR imaging were assessed with immunohistochemistry.
resultsMP2RAGE detected 203 cortical lesions (median, 16 lesions/case; interquartile range, 15), compared to 92 with T2*gradient-echo (median, 7; interquartile range, 8;
conclusionsA combination of MP2RAGE and T2*-weighted imaging at 7T improved detection of cortical lesions and should enable longitudinal studies to elucidate their spatiotemporal dynamics and clinical implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.