ArticleClinical journal of the American Society of Nephrology : CJASN2018
Serum Sodium and Cognition in Older Community-Dwelling Men.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Magnesium and Cognitive Health in Adults: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2024Pooled it
- Impact of High Dietary Salt on Neurovascular and Cognitive Functions.Hypertension (Dallas, Tex. : 1979) · 2026Review
- Association of Serum Sodium Levels and Delirium in Patients with Sepsis: A Retrospective Study.Biomedicines · 2026Article
- Cognition and fall assessment after recovery from syndrome of inappropriate anti diuresis.Endocrine · 2025Article
- Reassessing the Role of Copeptin in Emergency Department Admissions for Hypotonic Hyponatremia.The Journal of clinical endocrinology and metabolism · 2025Article
- Dietary salt, vascular dysfunction, and cognitive impairment.Cardiovascular research · 2025Review
- Treatment of hyponatremia: comprehension and best clinical practice.Clinical and experimental nephrology · 2025Review
- Pathophysiology, symptoms, outcomes, and evaluation of hyponatremia: comprehension and best clinical practice.Clinical and experimental nephrology · 2025Review
- The potential role and mechanism of Rhizoma Coptidis in prevention of diabetic encephalopathy: targeting sodium ion and channels.Frontiers in pharmacology · 2025Article
- The relationship between mineral mixture intake and cognitive function in older US adults: a cross-sectional NHANES study.The journal of nutrition, health & aging · 2024Article
- Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential.Signal transduction and targeted therapy · 2024Review
- Joint association of serum sodium and frailty with mild cognitive impairment among hospitalized older adults with chronic diseases: a cross-sectional study.Frontiers in nutrition · 2024Article
- Serum sodium improvement: change in Comprehensive Geriatric Assessment parameters in geriatric patients with hyponatremia.BMC geriatrics · 2023Article
- Dietary sodium/potassium intake and cognitive impairment in older patients with hypertension: Data from NHANES 2011-2014.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- The Association between Dysnatraemia during Hospitalisation and Post-COVID-19 Mental Fatigue.Journal of clinical medicine · 2023Article
- Hyponatremia and Cancer: From Bedside to Benchside.Cancers · 2023Review
- Serum sodium, cognition and incident dementia in the general population.Age and ageing · 2023Article
- Approach to the Patient: Hyponatremia and the Syndrome of Inappropriate Antidiuresis (SIAD).The Journal of clinical endocrinology and metabolism · 2022Review
- Hyponatremic Cognitive Dysfunction Resulting from Drug-Drug-Gene Interaction between Sertraline and Cannabidiol in an Intermediate CYP2C19 Metabolizer Patient.Innovations in pharmacy · 2022Article
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Authors and funding
8 authors.
Funding
Abstract
BACKGROUND AND
objectivesMild hyponatremia is a common finding in older adults; however, the association of lower serum sodium with cognition in older adults is currently unknown. We determined whether lower normal serum sodium is associated with cognitive impairment and risk of cognitive decline in community-dwelling older men. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Five thousand four hundred thirty-five community-dwelling men aged ≥65 years who participated in Osteoporotic Fractures in Men, a cohort study with a median follow-up for cognitive function of 4.6 years, were included in this analysis. Multivariable logistic regression was used to examine the association between baseline fasting serum sodium levels and the odds of prevalent cognitive impairment (cross-sectional analysis; modified Mini-Mental Status [3MS] score <1.5 SD [<84] below or Trail Making Test Part B time >1.5 SD above the mean [>223 seconds]) and cognitive decline (prospective analysis [
resultsParticipants were aged 74±6 years with a fasting mean serum sodium level of 141±3 mmol/L. Fifteen percent (
conclusionsIn community-dwelling older men, serum sodium between 126-140, and 126-140 or 143-153 mmol/L, are independently associated with prevalent cognitive impairment and cognitive decline, respectively.
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