Evidence map›Paper›PMID 29439087›Full record

ArticleMolecular pharmacology2018

High Constitutive Activity Accounts for the Combination of Enhanced Direct Activation and Reduced Potentiation in Mutated GABA

Allison L Germann, Daniel J Shin, Christina R Kuhrau, Alexander D Johnson, Alex S Evers, Gustav Akk

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Structural insights into GABANature communications · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution.

Allison L GermannDepartment of Anesthesiology (A.L.G., D.J.S., C.R.K., A.D.J., A.S.E., G.A.) and Taylor Family Institute for Innovative Psychiatric Research (A.S.E., G.A.), Washington University School of Medicine, St. Louis, Missouri.
Daniel J ShinDepartment of Anesthesiology (A.L.G., D.J.S., C.R.K., A.D.J., A.S.E., G.A.) and Taylor Family Institute for Innovative Psychiatric Research (A.S.E., G.A.), Washington University School of Medicine, St. Louis, Missouri.
Christina R KuhrauDepartment of Anesthesiology (A.L.G., D.J.S., C.R.K., A.D.J., A.S.E., G.A.) and Taylor Family Institute for Innovative Psychiatric Research (A.S.E., G.A.), Washington University School of Medicine, St. Louis, Missouri.
Alexander D JohnsonDepartment of Anesthesiology (A.L.G., D.J.S., C.R.K., A.D.J., A.S.E., G.A.) and Taylor Family Institute for Innovative Psychiatric Research (A.S.E., G.A.), Washington University School of Medicine, St. Louis, Missouri.
Alex S EversDepartment of Anesthesiology (A.L.G., D.J.S., C.R.K., A.D.J., A.S.E., G.A.) and Taylor Family Institute for Innovative Psychiatric Research (A.S.E., G.A.), Washington University School of Medicine, St. Louis, Missouri.
Gustav AkkDepartment of Anesthesiology (A.L.G., D.J.S., C.R.K., A.D.J., A.S.E., G.A.) and Taylor Family Institute for Innovative Psychiatric Research (A.S.E., G.A.), Washington University School of Medicine, St. Louis, Missouri akk@morpheus.wustl.edu.
Taylor Family Institute for Innovative Psychiatric Research

Funding

MOLECULAR SITES OF NEUROSTEROID BINDINGR01GM108799 · NIGMS · WASHINGTON UNIVERSITY · PI EVERS, ALEX S. · 2014 to 2022
$4.0M
SYNERGISTIC ACTIONS OF INTRAVENOUS ANESTHETICSR01GM108580 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2014 to 2021
$2.4M
NIGMS NIH HHS R01 GM108580NIGMS NIH HHS R01 GM108799
6 · The paper itself

Abstract

GABA

Indexed as

MutationAllosteric RegulationAnesthetics, IntravenousAnimalsCells, CulturedDrug SynergismGABA Agonistsgamma-Aminobutyric AcidHumansPropofolReceptors, GABA-AXenopusAnesthetics, IntravenousGABA Agonistsgamma-Aminobutyric AcidPropofolReceptors, GABA-A

Identifiers

PMID29439087
PMCPMC5878668
OpenAlexW2788683290

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.