ArticleBMJ open2018
Long-term trends of liver cancer mortality by gender in urban and rural areas in China: an age-period-cohort analysis.
Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association Between Environmental and Socioeconomic Risk Factors and Hepatocellular Carcinoma: A Meta-Analysis.Frontiers in public health · 2022Pooled it
- Persistent and widening geographic disparities in liver cancer mortality in China, 1987-2021: a 35-year analysis from a national perspective.Journal of the National Cancer Center · 2026Article
- Global trends and epidemiological shifts in gastrointestinal cancers: insights from the past four decades.Cancer communications (London, England) · 2025Article
- Factors affecting the place of death in patients with liver cancer in China, 2013-2020: A population-based study.Cancer pathogenesis and therapy · 2025Article
- Identification of 1-Methylnicotinamide as a specific biomarker for the progression of cirrhosis to hepatocellular carcinoma.Journal of cancer research and clinical oncology · 2024Article
- Mortality Burden of Liver Cancer in China: An Observational Study From 2008 to 2020.Journal of clinical and translational hepatology · 2024Article
- Patients with chronic hepatitis B who have persistently normal alanine aminotransferase or aged < 30 years may exhibit significant histologic damage.BMC gastroenterology · 2024Article
- Trend analysis and age-period-cohort effects on morbidity and mortality of liver cancer from 2010 to 2020 in Guangzhou, China.Frontiers in oncology · 2024Article
- Contribution of alcohol use to the global burden of cirrhosis and liver cancer from 1990 to 2019 and projections to 2044.Hepatology international · 2023Article
- Trends of Mortality in End-Stage Liver Disease - China, 2008-2020.China CDC weekly · 2023Article
- Burden of liver cancer: From epidemiology to prevention.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2022Article
- [Expanding antiviral therapy for chronic hepatitis B: scale up screening and treatment].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Article
- [Expert opinion on expanding anti-HBV treatment for chronic hepatitis B].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Article
- [Should both patient's age and family history be necessary as the criteria for initiating treatment of HBeAg-positive or negative patients with chronic hepatitis B virus infection and normal alanine aminotransferase?]Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Article
- Current treatment of chronic hepatitis B: Clinical aspects and future directions.Frontiers in microbiology · 2022Review
- Influence of Demographic Factors on Long-Term Trends of Premature Mortality and Burden Due to Liver Cancer: Findings From a Population-Based Study in Shanghai, China, 1973-2019.Frontiers in public health · 2022Article
- Contrasting Trends of Primary Liver Cancer Mortality in Chinese Mongol and Non-Mongol.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Remoteness of residence predicts tumor stage, receipt of treatment, and mortality in patients with hepatocellular carcinoma.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Time trends of major cancers incidence and mortality in Guangzhou, China 2004-2015: A Joinpoint and Age-Period-Cohort Analysis.Cancer medicine · 2021Article
- The Impact of Geography in Hepatocellular Carcinoma: A Retrospective Population Based Study.Current oncology (Toronto, Ont.) · 2021Article
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Authors and funding
9 authors.
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Abstract
objectivesTo provide an up-to-date overview of long-term trends of liver cancer mortality and evaluate the effects attributable to age, period and cohort in Chinese population stratified by gender and urban/rural areas.
methodsPopulation and liver cancer mortality data were obtained based on the Disease Surveillance Points in China from 1991 to 2014. To examine the time trends of liver cancer mortality by gender in urban and rural areas in China, Joinpoint analysis was used to estimate the annual per cent change. The intrinsic estimator, a method of age-period-cohort analysis to estimate age, period and cohort effects simultaneously, was used to analyse the underlying mechanisms for liver cancer mortality trends in the aforementioned four groups.
resultsWe observed a significant decline in liver cancer mortality for urban men (average annual per cent change (AAPC)=-1.1%, P<0.05) and urban women (AAPC=-1.4%, P<0.05), while the liver cancer mortality remained stable for rural men (AAPC=-0.1%, P>0.05) and rural women (AAPC=-0.9%, P>0.05). Compared with the 15-19 age group, the liver cancer mortality risk of the 85 and above age group increased 65 and 42 times for urban and rural men, and 102 and 70 times for urban and rural women. From the 1990-1994 period to the 2005-2009 period, the risk increased 56% and 92% for urban and rural men, and 30% and 74% for urban and rural women. Compared with period and cohort effects, age effects were the most influential factor in liver cancer mortality.
conclusionsAs the status of ageing population in China gets worse, the burden caused by liver cancer mortality could still be a great challenge for China in the future. The disparity of liver cancer mortality trends between urban and rural residents can be attributed to period effects, referring to the unequal medical levels and resources between urban and rural areas.
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