Evidence map›Paper›PMID 29438979›Full record

ArticleEMBO reports2018

Mitochondrial tyrosyl-DNA phosphodiesterase 2 and its TDP2

Shar-Yin N Huang, Ilaria Dalla Rosa, Stephanie A Michaels, David V Tulumello, Keli Agama, Salim Khiati, Sae Rin Jean, Simone A Baechler, Valentina M Factor, Sudhir Varma and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

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  12. Twist and Turn-Topoisomerase Functions in Mitochondrial DNA Maintenance.International journal of molecular sciences · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Shar-Yin N HuangLaboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA shar-yin.huang@nih.gov pommier@nih.gov.
Ilaria Dalla RosaLaboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Stephanie A MichaelsLaboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
David V TulumelloDepartment of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Keli AgamaLaboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Salim KhiatiLaboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Sae Rin JeanDepartment of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Simone A BaechlerLaboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Valentina M FactorLaboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Sudhir VarmaLaboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Junko MuraiLaboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Lisa M Miller JenkinsLaboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Shana O KelleyDepartment of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Yves PommierLaboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA shar-yin.huang@nih.gov pommier@nih.gov.ORCID 0000-0002-3108-0758
National Cancer Institute · USUniversity of Toronto · CA

Funding

PROTEIN-ASSOCIATED DNA BREAKS AS INDICATOR OF TOPOISOMERASE INHIBITIONZ01BC006150 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI POMMIER, YVES · 1996 to 2008
$1.5M
Functional genetic screening to elucidate novel mitochondrial DNA repair factors using organelle-targeted chemical probesR01GM116886 · NIGMS · UNIVERSITY OF TORONTO · PI KELLEY, SHANA O · 2017 to 2020
$734k
Intramural NIH HHS Z01 BC006150NIGMS NIH HHS R01 GM116886
6 · The paper itself

Abstract

Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs abortive topoisomerase II cleavage complexes. Here, we identify a novel short isoform of TDP2 (TDP2

Indexed as

Alternative SplicingCell Line, TumorDNA-Binding ProteinsDoxorubicinDrug Resistance, NeoplasmGene Expression Regulation, EnzymologicGene Knockout TechniquesHumansMitochondriaNeoplasmsNuclear ProteinsPhosphoric Diester HydrolasesProtein IsoformsTranscription FactorsDNA-Binding ProteinsDoxorubicinNuclear ProteinsPhosphoric Diester HydrolasesProtein IsoformsTDP2 protein, humanTranscription FactorsDNA repairmitochondriamitochondrial DNAtopoisomerase

Identifiers

PMID29438979
PMCPMC5836098
OpenAlexW2787333227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.