ArticleThe Journal of allergy and clinical immunology2018
Lumen area change (Delta Lumen) between inspiratory and expiratory multidetector computed tomography as a measure of severe outcomes in asthmatic patients.
Article in The Journal of allergy and clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The Evaluation of the Inner Diameter of the Airway in Asthma Recovery by using HRCT: A Retrospective Observational Cohort StudyCurrent medical imaging · 2026Observational
- Novel Tracheal Parameters Based on Quantitative Computed Tomography Assessment Reflecting Pulmonary Function and Eosinophilia in Patients With Asthma Who Demonstrate Persistent Airflow Obstruction: A Retrospective Observational Cross-Sectional Study.Health science reports · 2025Article
- Automated CT-based measurements of radial and longitudinal expansion of airways due to breathing-related lung volume change.Medical physics · 2025Article
- The New Paradigm: The Role of Proteins and Triggers in the Evolution of Allergic Asthma.International journal of molecular sciences · 2024Review
- Differences in the Quantitative HRCT Characteristics of Patients with Asthma, COPD and Asthma-COPD Overlap and Their Relationships with Pulmonary Function.International journal of chronic obstructive pulmonary disease · 2024Article
- Imaging Regional Airway Involvement of Asthma: Heterogeneity in Ventilation, Mucus Plugs and Remodeling.Advances in experimental medicine and biology · 2023Article
- Novel Lung Growth Strategy with Biological Therapy Targeting Airway Remodeling in Childhood Bronchial Asthma.Children (Basel, Switzerland) · 2022Review
- Fetal Origins of Asthma: A Longitudinal Study from Birth to Age 36 Years.American journal of respiratory and critical care medicine · 2020Article
- Status and prospects: personalized treatment and biomarker for airway remodeling in asthma.Journal of thoracic disease · 2020Review
- Quantitative CT-based structural alterations of segmental airways in cement dust-exposed subjects.Respiratory research · 2020Article
- Article
- Compressive air trapping in asthma: effects of age, sex, and severity.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Airway wall thickness and airflow limitations in asthma assessed in quantitative computed tomography.Therapeutic advances in respiratory diseaseArticle
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Authors and funding
14 authors.
Funding
Abstract
backgroundQuantitative computed tomographic (QCT) biomarkers of airway morphology hold potential for understanding and monitoring regional airway remodeling in asthmatic patients.
objectiveWe sought to determine whether the change in airway lumen area between total lung capacity (TLC) and functional residual capacity (FRC) lung volumes measured from CT imaging data was correlated with severe outcomes in asthmatic patients.
methodsWe studied 152 asthmatic patients (90 female and 62 male patients) and 33 healthy subjects (12 female and 21 male subjects) using QCT. Postprocessing of airways at generations 1 to 5 (1 = trachea) was performed for wall area percentage, wall thickness percentage (WT%), lumen area at baseline total lung capacity (LA
resultsPostprocessing of 4501 airway segments was performed (3681 segments in the 152 patients with asthma and 820 segments in the 33 healthy subjects; range, 17-28 segments per subject). Delta Lumen values were negatively correlated with WT% and low attenuation area (P < .01) in asthmatic patients. Delta Lumen values were significantly lower for airway generations 3 to 5 (segmental airways) in subjects undergoing hospitalization because of exacerbation and in patients with refractory asthma requiring treatment with systemic corticosteroids. WT% and low attenuation area were positively and Delta Lumen values were negatively associated with systemic corticosteroid treatment (P < .05), suggesting that a reduced Delta Lumen value is a potential outcome biomarker in patients with severe asthma.
conclusionReduced Delta Lumen value in the central airways measured by using QCT is a promising exploratory biomarker of unstable refractory asthma that warrants further study.
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