ArticleJournal of neurology, neurosurgery, and psychiatry1986
Peripheral blood T lymphocyte changes in multiple sclerosis: a marker of disease progression rather than of relapse?
Article in Journal of neurology, neurosurgery, and psychiatry, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- The CD8 T Cell-Epstein-Barr Virus-B Cell Trialogue: A Central Issue in Multiple Sclerosis Pathogenesis.Frontiers in immunology · 2021Review
- Herpes Simplex Virus Type 1 Infection of the Central Nervous System: Insights Into Proposed Interrelationships With Neurodegenerative Disorders.Frontiers in cellular neuroscience · 2019Review
- The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases.Molecular neurodegeneration · 2017Review
- Deficiency of CD8+ effector memory T cells is an early and persistent feature of multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2014Article
- Genetics and autoantibodies.Immunologic research · 2013Review
- CD8 T cell deficiency impairs control of Epstein--Barr virus and worsens with age in multiple sclerosis.Journal of neurology, neurosurgery, and psychiatry · 2012Article
- CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis.Autoimmune diseases · 2012Article
- Decreased CD8+ T cell response to Epstein-Barr virus infected B cells in multiple sclerosis is not due to decreased HLA class I expression on B cells or monocytes.BMC neurology · 2011Article
- The essential role of Epstein-Barr virus in the pathogenesis of multiple sclerosis.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2011Review
- Epidemiologic evidence for multiple sclerosis as an infection.Clinical microbiology reviews · 1993Review
- Presence of T-cell subset abnormalities in newly diagnosed cases of multiple sclerosis and relationship with short-term clinical activity.Journal of neurology · 1993Article
- Serial studies of evoked potentials and circulating lymphocyte subsets for multiple sclerosis: attempts to monitor progress.Journal of neurology · 1990Article
- T cell subsets and disease progression after total lymphoid irradiation in chronic progressive multiple sclerosis.Journal of neurology, neurosurgery, and psychiatry · 1988Article
- Determination of activated lymphocytes in peripheral blood of patients with multiple sclerosis.Journal of neurology, neurosurgery, and psychiatry · 1988Article
- T-lymphocyte subpopulations in multiple sclerosis--do they help to judge immunosuppressive therapy?European archives of psychiatry and neurological sciences · 1988Article
- The pathogenesis of multiple sclerosis. The Bradshaw lecture 1986.Journal of the Royal College of Physicians of London · 1987Review
- Cerebrospinal fluid and peripheral blood T-lymphocyte subsets in multiple sclerosis: monoclonal antibody analysis and correlations with clinical activity.Italian journal of neurological sciences · 1987Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A serial study of peripheral blood T lymphocytes in 27 patients with clinically definite multiple sclerosis and 11 healthy controls was carried out over a 12 month period. This showed that contrary to many previous reports, relapses were not consistently associated with reduced numbers of peripheral blood suppressor T lymphocytes or any other T cells. Persistently low T cells numbers, including both the helper and suppressor T cell subsets, were, however, associated with disease activity as measured by the development of increased disability during the course of the study. This was true both for the patients with relapsing/remitting disease and those with progressive disease. The importance of carrying out a serial study was emphasised by the consistent and significant differences that were detected between individuals in both the control and the patient groups. A serial study is the most reliable means by which clinical events can clearly be correlated with laboratory estimations. The association in this study between the development of increased disability and persistently low levels of peripheral blood T lymphocytes suggest that both may be related to the underlying disease process in multiple sclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.