Evidence map›Paper›PMID 29438699›Full record

ArticleCancer cell2018

DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk.

Wenbing Xie, Ioannis Kagiampakis, Lixia Pan, Yang W Zhang, Lauren Murphy, Yong Tao, Xiangqian Kong, Byunghak Kang, Limin Xia, Filipe L F Carvalho and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Dilating the aging clock with light.Innovation (Cambridge (Mass.)) · 2026
    Review
  6. Review
  7. Epigenetic Instability-Based Metrics in Cell-Free DNA for Early Cancer Detection.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  8. mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Interrogating the regulatory epigenome of cellular senescence.Cellular and molecular life sciences : CMLS · 2025
    Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Wenbing XieThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Ioannis KagiampakisThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Lixia PanLaboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Yang W ZhangThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Lauren MurphyThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Yong TaoThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Xiangqian KongThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Byunghak KangThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Limin XiaThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Filipe L F CarvalhoThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Subhojit SenUM-DAE Center for Excellence in Basic Sciences (CBS), Mumbai University, Mumbai 400098, India.
Ray-Whay Chiu YenThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Cynthia A ZahnowThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Nita AhujaThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Stephen B BaylinThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: sbaylin@jhmi.edu.
Hariharan EaswaranThe Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: heaswar2@jhmi.edu.
Johns Hopkins University · USSidney Kimmel Comprehensive Cancer Center · USNational Institutes of Health · USUniversity of Mumbai · IN

Funding

Epigenetic Drivers of Cancer (PQ 10)R01CA170550 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI BAYLIN, STEPHEN B., JONES, PETER A · 2012 to 2015
$2.4M
(PQD3)Molecular Profiles associated with Long-Term Survival in pancreas CancerR01CA185357 · NCI · YALE UNIVERSITY · PI AHUJA, NITA · 2014 to 2017
$1.8M
High-efficiency microfluidic-assisted single-cell DNA methylome sequencingR21CA212495 · NCI · JOHNS HOPKINS UNIVERSITY · PI EASWARAN, HARIHARAN, PISANIC II, THOMAS RUSSELL · 2017 to 2019
$729k
NCI NIH HHS R01 CA170550NCI NIH HHS R01 CA185357NCI NIH HHS R21 CA212495
6 · The paper itself

Abstract

Overall shared DNA methylation patterns between senescence (Sen) and cancers have led to the model that tumor-promoting epigenetic patterns arise through senescence. We show that transformation-associated methylation changes arise stochastically and independently of programmatic changes during senescence. Promoter hypermethylation events in transformation involve primarily pro-survival and developmental genes, similarly modified in primary tumors. Senescence-associated hypermethylation mainly involves metabolic regulators and appears early in proliferating "near-senescent" cells, which can be immortalized but are refractory to transformation. Importantly, a subset of transformation-associated hypermethylated developmental genes exhibits highest methylation gains at all age-associated cancer risk states across tissue types. These epigenetic changes favoring cell self-renewal and survival, arising during tissue aging, are fundamentally important for stratifying cancer risk and concepts for cancer prevention.

Indexed as

AnimalsCell Transformation, NeoplasticCellular SenescenceCpG IslandsDNA MethylationEpigenesis, GeneticHumansMiceMice, SCIDNeoplasmsPromoter Regions, GeneticRiskagingcancercancer riskDNA methylationepigeneticmalignant transformationoncogene-induced senescencepromoter CpG-islandsenescence

Identifiers

PMID29438699
PMCPMC5813821
OpenAlexW2785550069

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.