Evidence map›Paper›PMID 29438691›Full record

ArticleCancer cell2018

HIPPO Stampede in Nerve Sheath Tumors.

M Laura Feltri, Yannick Poitelon

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cancer cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

M Laura FeltriHunter James Kelly Research Institute, Departments of Biochemistry and Neurology, University at Buffalo, Buffalo, NY 14203, USA. Electronic address: mlfeltri@buffalo.edu.
Yannick PoitelonAlbany Medical College, Department of Neuroscience and Experimental Therapeutics, Albany, NY 12208, USA.
Albany Medical Center Hospital · USUniversity at Buffalo, State University of New York · US

Funding

Laminin Receptors and Signals in Schwann CellsR01NS045630 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI SIM, FRASER JAMES · 2003 to 2024
$5.9M
NINDS NIH HHS R01 NS045630
6 · The paper itself

Abstract

Current therapies for malignant peripheral nerve sheath tumors (MPNSTs) are ineffective. The study by Wu et al. in this issue of Cancer Cell provides evidence that the HIPPO pathway is overactive in human MPNSTs and that combined modulation of LATS1/2-YAP/TAZ and PDGFR signaling in Schwann cells reduces MPNST growth.

Indexed as

Nerve Sheath NeoplasmsSignal TransductionHippo Signaling PathwayHumansProtein Serine-Threonine KinasesSchwann CellsProtein Serine-Threonine Kinases

Identifiers

PMID29438691
OpenAlexW2788864121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.