ArticleJournal of molecular biology2018
The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism.
Article in Journal of molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Who cites it
35 citing papers in PubMed.
- Should I stay or should I go? DNA damage thresholds drive stay-or-go decisions inJournal of bacteriology · 2026Review
- Whole-Genome Sequencing of Multidrug-ResistantInternational journal of molecular sciences · 2026Article
- Bacteriophages targetingFrontiers in microbiology · 2026Review
- Exploration of Phosphoproteins inPathogens (Basel, Switzerland) · 2025Article
- A phosphorylation signal activates genome-wide transcriptional control by BfmR, the global regulator of Acinetobacter resistance and virulence.Nucleic acids research · 2025Article
- The BfmRS stress response protectsJournal of bacteriology · 2025Article
- Discovery of novel BfmR inhibitors restoring carbapenem susceptibility against carbapenem-resistantEmerging microbes & infections · 2024Article
- A phosphorylation signal activates genome-wide transcriptional control by BfmR, the global regulator ofbioRxiv : the preprint server for biology · 2024Article
- Acinetobacter baumannii as an oro-dental pathogen: a red alert!!Journal of applied oral science : revista FOB · 2024Review
- Article
- Assesment of polyphenolic compounds against biofilms produced by clinicalSaudi journal of biological sciences · 2023Article
- Unlocking the Antibiofilm Potential of Natural Compounds by Targeting the NADH:quinone Oxidoreductase WrbA.Antioxidants (Basel, Switzerland) · 2023Article
- Genome-wide phage susceptibility analysis in Acinetobacter baumannii reveals capsule modulation strategies that determine phage infectivity.PLoS pathogens · 2023Article
- BfmRS encodes a regulatory system involved in light signal transduction modulating motility and desiccation tolerance in the human pathogen Acinetobacter baumannii.Scientific reports · 2023Article
- Complementary Regulation of BfmRS Two-Component and AbaIR Quorum Sensing Systems to Express Virulence-Associated Genes inInternational journal of molecular sciences · 2022Article
- Acinetobacter baumannii Regulates Its Stress Responses via the BfmRS Two-Component Regulatory System.Journal of bacteriology · 2022Article
- Structure of the Acinetobacter baumannii PmrA receiver domain and insights into clinical mutants affecting DNA binding and promoting colistin resistance.Journal of biochemistry · 2022Article
- Factors mediatingCurrent research in microbial sciences · 2022Review
- Targeted specific inhibition of bacterial andRSC advances · 2021Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The rise of drug-resistant bacterial infections coupled with decreasing antibiotic efficacy poses a significant challenge to global health care. Acinetobacter baumannii is an insidious, emerging bacterial pathogen responsible for severe nosocomial infections aided by its ability to form biofilms. The response regulator BfmR, from the BfmR/S two-component system, is the master regulator of biofilm initiation in A. baumannii and is a tractable therapeutic target. Here we present the structure of A. baumannii BfmR using a hybrid approach combining X-ray crystallography, nuclear magnetic resonance spectroscopy, chemical crosslinking mass spectrometry, and molecular modeling. We also show that BfmR binds the previously proposed bfmRS promoter sequence with moderate affinity. While BfmR shares many traits with other OmpR/PhoB family response regulators, some unusual properties were observed. Most importantly, we observe that when phosphorylated, BfmR binds this promoter sequence with a lower affinity than when not phosphorylated. All other OmpR/PhoB family members studied to date show an increase in DNA-binding affinity upon phosphorylation. Understanding the structural and biochemical mechanisms of BfmR will aid in the development of new antimicrobial therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.