ArticleArthritis care & research2018
Increased Burden of Psychiatric Disorders in Rheumatoid Arthritis.
Article in Arthritis care & research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review and meta-analysis of the kynurenine pathway of tryptophan metabolism in rheumatic diseases.Frontiers in immunology · 2023Pooled it
- Rheumatoid arthritis and risk of anxiety: a meta-analysis of cohort studies.Clinical rheumatology · 2019Pooled it
- Associations Between Non-neurological Autoimmune Disorders and Psychosis: A Meta-analysis.Biological psychiatry · 2019Pooled it
- Risk prediction rules in individuals at risk of rheumatoid arthritis: systematic review and validation using the APIPPRA cohort.EULAR rheumatology open · 2026Article
- Documented Rheumatic Disease and Post-Discharge Mortality After Acute Coronary Syndrome: A Two-Center Registry Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Article
- Immunometabolic and brain structural alterations mediate increased risk of brain diseases in rheumatoid arthritis patients.Translational psychiatry · 2025Article
- Influence of Sociodemographic and Lifestyle Factors on Depression and Anxiety in Patients with Rheumatoid Arthritis in Saudi Arabia.International journal of environmental research and public health · 2025Article
- Risk factors, protective factors, peripheral biomarkers, and neurocognitive markers associated with mood disorders: An umbrella review of 103 meta-analyses and systematic reviews.Brain, behavior, & immunity - health · 2025Review
- Preclinical Evaluation of Nanoemulsion and Polymeric Nanocapsule Delivery Systems of 4-(Phenylselanyl)-2H-Chromen-2-One for Rheumatoid Arthritis and Comorbidities.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Association of psychiatric comorbidities with chronic urticaria: a nested case-control study in the All of Us research program.JEADV clinical practice · 2025Article
- Neurodevelopmental origins of structural and psychomotor defects in CXCR4-linked primary immunodeficiency.Neuron · 2025Article
- Association of TNF-α and IL-6 Concentrations with Depression in Patients with Rheumatoid Arthritis.Current issues in molecular biology · 2025Article
- Trends in Anxiety and Depression Among Individuals With Rheumatoid Arthritis: A Population-Based Study.The Journal of rheumatology · 2025Article
- Rheumatoid arthritis and risk of hearing impairment: A genetic correlation and bidirectional Mendelian randomization study.Medicine · 2025Article
- Do individuals with inflammatory arthritis receive minimally adequate treatment for incident depression and anxiety: A population-based study.Arthritis research & therapy · 2025Article
- Associations between childhood trauma, depression, anxiety disorders and early arthritis presence.Frontiers in medicine · 2025Article
- Racial differences in the incidence of mental health illness among ovarian cancer patients: An analysis of SEER-Medicare data.SSM. Mental health · 2024Article
- Association of improvement and worsening of depressive symptoms with arthritis.BMC geriatrics · 2024Article
- Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
objectiveWe estimated the incidence and prevalence of depression, anxiety disorder, bipolar disorder, and schizophrenia in a population-based cohort with rheumatoid arthritis (RA) as compared to an age-, sex-, and geographically matched cohort without RA.
methodsUsing population-based administrative health data from Manitoba, Canada, we identified persons with incident RA between 1989 and 2012, and a cohort from the general population matched 5:1 on year of birth, sex, and region of residence. We applied validated algorithms for depression, anxiety disorder, bipolar disorder, and schizophrenia to determine the annual incidence of these conditions after the diagnosis of RA, and their lifetime and annual period prevalence. We compared findings between cohorts using negative binomial regression models.
resultsWe identified 10,206 incident cases of RA and 50,960 matched individuals. After adjustment for age, sex, socioeconomic status, region of residence, number of physician visits, and year, the incidence of depression was higher in the RA cohort over the study period (incidence rate ratio [IRR] 1.46 [95% confidence interval (95% CI) 1.35-1.58]), as was the incidence of anxiety disorder (IRR 1.24 [95% CI 1.15-1.34]) and bipolar disorder (IRR 1.21 [95% CI 1.00-1.47]). The incidence of schizophrenia did not differ between groups (IRR 0.96 [95% CI 0.61-1.50]). Incidence rates of psychiatric disorders declined minimally over time. The lifetime and annual period prevalence of depression and anxiety disorder were also higher in the RA than in the matched cohort over the study period.
conclusionThe incidence and prevalence of depression, anxiety disorder, and bipolar disorder are elevated in the RA population as compared to a matched population.
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