ArticleArthritis care & research2018
From Early Radiographic Knee Osteoarthritis to Joint Arthroplasty: Determinants of Structural Progression and Symptoms.
Article in Arthritis care & research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 26 citations in OpenAlex.
- A clinical model for predicting knee replacement in early-stage knee osteoarthritis: data from osteoarthritis initiative.Clinical rheumatology · 2022Trial
- Effusion and synovial hyperplasia: Distinct constructs in early and late-stage knee OA.Osteoarthritis imaging · 2026Article
- Characterizing symptom burden in knee osteoarthritis: the predominant role of Kellgren-Lawrence grade 4 in functional decline and pain severity.Rheumatology international · 2026Article
- Early detection of knee osteoarthritis - The role of a composite disease activity metric: Data from the Osteoarthritis Initiative.Osteoarthritis and cartilage open · 2026Article
- Clinical validation of fully automated (peri-)articular tissue analysis for assessing osteoarthritis progression: A narrative review.Osteoarthritis and cartilage open · 2026Review
- Cartilage loss is greater in knees with virtual joint replacement status than in matched controls without.Osteoarthritis and cartilage open · 2025Article
- Influencing factors of flexion contracture among patients with knee osteoarthritis: a multi-center retrospective cross-sectional study.Scientific reports · 2025Article
- Arthroscopic-Assisted Management of Subchondral Bone Marrow Lesions of the Knee.Arthroscopy techniques · 2025Article
- Imaging-based measures of synovitis in knee osteoarthritis: A scoping review and narrative synthesis.Osteoarthritis and cartilage open · 2025Review
- Infrapatellar fat pad as a source of biomarkers and therapeutic target for knee osteoarthritis.Arthritis research & therapy · 2025Review
- Comparison of Inflammatory Biomarkers in Females with and Without Patellofemoral Pain and Associations with Patella Position, Hip and Knee Kinematics, and Pain.Biomedicines · 2025Article
- Association of MRI-based knee osteoarthritis structural phenotypes with short-term structural progression and subsequent total knee replacement.Journal of orthopaedic surgery and research · 2024Article
- Efficacy of Combining Whole-body Vibration Training and Closed Kinetic Chain Exercises in Early Knee Osteoarthritis: A Preliminary Study.Progress in rehabilitation medicine · 2024Article
- Classifying Pre-Radiographic Osteoarthritis of the Knee Using Wearable Acoustics Sensing at the Point of Care.IEEE sensors journal · 2023Article
- Exploring molecular mechanisms underlying the pathophysiological association between knee osteoarthritis and sarcopenia.Osteoporosis and sarcopenia · 2023Article
- Subchondral tibial bone texture of conventional X-rays predicts total knee arthroplasty.Scientific reports · 2022Article
- Common Biochemical and Magnetic Resonance Imaging Biomarkers of Early Knee Osteoarthritis and of Exercise/Training in Athletes: A Narrative Review.Diagnostics (Basel, Switzerland) · 2021Review
- Predictive value of magnetic resonance imaging (MRI) measures for the occurrence of total knee arthroplasty in knee osteoarthritis.Annals of translational medicine · 2020Article
- Viscoelasticity and histology of the human cartilage in healthy and degenerated conditions of the knee.Journal of orthopaedic surgery and research · 2019Article
- Chondroprotective Factors in Osteoarthritis: a Joint Affair.Current rheumatology reports · 2019Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 5 countries.
Funding
Abstract
objectiveTo assess structural progression in knees with no/mild radiographic osteoarthritis (OA) (i.e., Kellgren/Lawrence [K/L] grades 0-2) that will undergo knee replacement during a 5-year period; to assess differences in structural damage on magnetic resonance imaging (MRI) in knees with no/mild radiographic OA versus those with severe radiographic OA (i.e., K/L grades 3 and 4) at baseline; and to assess differences in pain levels between those groups.
methodsAll participants who underwent knee replacement from baseline to 60 months were drawn from the Osteoarthritis Initiative. MRIs were assessed for bone marrow lesions (BMLs), Hoffa synovitis, and effusion synovitis (i.e., hyperintensity signal changes in the fat pad and abnormal amount of capsular distension due to intraarticular joint fluid and/or synovial thickening) at baseline and at the time point before knee replacement (T0). The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Knee Injury and Osteoarthritis Outcome Score (KOOS) pain were used for pain characterization. WOMAC activities of daily living and KOOS quality of life were applied to characterize functional status of the included participants. Logistic regression was used to assess the association of no/mild radiographic OA with these MRI features and pain.
resultsBased on inclusion criteria, 181 knees were selected. Participants were predominantly female (57.8%) with a mean age of 64.4 years. A total of 51 knees (28.2%) had no/mild radiographic OA at baseline. Of these, 51.0% progressed to severe radiographic OA. No/mild radiographic OA knees showed higher odds of BMLs in the patellofemoral joint at baseline (odds ratio [OR] 7.92 [95% confidence interval (95% CI) 3.45-18.16]) and T0 (OR 9.44 [95% CI 4.00-22.28]) compared to severe radiographic OA knees. In addition, no/mild radiographic OA knees were associated with change from no pain to pain from baseline to T0 (adjusted OR 5.48 [95% CI 1.25-24.00]).
conclusionMore than half of the knees with no/mild radiographic OA before knee replacement progressed to severe radiographic OA during 4 years of follow-up. BMLs in the patellofemoral joint were more often seen among knees that had no/mild radiographic OA. Worsening pain status may contribute to knee replacement in knees with no/mild radiographic OA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.