Evidence map›Paper›PMID 29438602›Full record

ArticleInternational forum of allergy & rhinology2018

International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis.

Sarah K Wise, Sandra Y Lin, Elina Toskala, Richard R Orlandi, Cezmi A Akdis, Jeremiah A Alt, Antoine Azar, Fuad M Baroody, Claus Bachert, G Walter Canonica and 62 more

3 registry-linked trialsOpen access · greenAbstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in International forum of allergy & rhinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 164 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed, 7 pooled it
36.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04465604 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Hypertonic saline coated face mask for reducing respiratory symptom severity in patients with covid-19

TypeinterventionalSponsorKing Faisal Specialist Hospital & Research CenterRan2021 to 2022Enrolled50ConditionsCOVID-19ArmsWearing surgical face mask sprayed with hypertonic saline
NCT05301647 completednot on this mapstarted 2019, after this paper: background citation

Mometasone Furoate Nasal Spray in Italian Children With Seasonal Allergic Rhinitis: a Comprehensive Assessment

TypeobservationalSponsorUniversity of Campania Luigi VanvitelliRan2019 to 2021Enrolled80ConditionsRhinitis, Allergic, Nasal Allergy, Allergy Pollen, Nasal, CytologyArmsNasal cytology, The validated Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ), Total symptom score (TSS), Visual analogic scale (VAS)
NCT05348148 narecruitingnot on this mapstarted 2020, after this paper: background citation

Camillian Saint Mary's Hospital Luodong

TypeinterventionalSponsorCamillians Saint Mary's Hospital LuodongRan2020 to 2032Enrolled450ConditionsAllergic Rhinitis, Vasomotor RhinitisArmsOral Levocetirizine, Combined Intranasal Mometasone Furoate with oral Levocetirizine, Combined Intranasal Mometasone Furoate with oral Levocetirizine plus intranasal Oxymetazoline
3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 7 syntheses or guidelines pooled it, 541 citations in OpenAlex.

  1. Comparison of turbinate volume reduction surgeries for nasal symptoms and surgery-related adverse effects in patients with chronic rhinitis: a systematic review and network meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Pooled it
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  8. Efficacy of nasal saline irrigation in conjunction with intranasal steroids in allergic rhinitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
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  9. Immature Sword Bean (Nutrients · 2025
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104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

72 authors at 20 institutions in 16 countries.

Sarah K WiseOtolaryngology, Emory University, USA.
Sandra Y LinOtolaryngology, Johns Hopkins University, USA.
Elina ToskalaOtolaryngology, Temple University, USA.
Richard R OrlandiOtolaryngology, University of Utah, USA.
Cezmi A AkdisAllergy/Asthma, Swiss Institute of Allergy and Asthma Research, Switzerland.
Jeremiah A AltOtolaryngology, University of Utah, USA.
Antoine AzarAllergy/Immunology, Johns Hopkins University, USA.
Fuad M BaroodyOtolaryngology, University of Chicago, USA.
Claus BachertOtolaryngology, University of Ghent, Belgium.
G Walter CanonicaRespiratory Diseases, Humanitas University, Italy.
Thomas ChackoAllergy/Immunology, Private Practice, USA.
Cemal CingiOtolaryngology, Eskisehir Osmangazi University, Turkey.
Giorgio CiprandiAllergy/Immunology, Ospedale Policlinico San Martino, Italy.
Jacquelynne CoreyOtolaryngology, University of Chicago, USA.
Linda S CoxAllergy/Immunology, Private Practice, USA.
Peter Socrates CreticosAllergy/Immunology, Johns Hopkins University, USA.
Adnan CustovicPediatric Allergy, Imperial College London, UK.
Cecelia DamaskOtolaryngology, Private Practice, USA.
Adam DeCondeOtolaryngology, University of California San Diego, USA.
John M DelGaudioOtolaryngology, Emory University, USA.
Charles S EbertOtolaryngology, University of North Carolina, USA.
Jean Anderson EloyOtolaryngology, Rutgers New Jersey Medical School, USA.
Carrie E FlanaganOtolaryngology, Emory University, USA.
Wytske J FokkensOtolaryngology, University of Amsterdam, Netherlands.
Christine FranzeseOtolaryngology, University of Missouri, USA.
Jan GosepathOtorhinolaryngology, Helios Kliniken Wiesbaden, Germany.
Ashleigh HaldermanOtolaryngology, University of Texas Southwestern, USA.
Robert G HamiltonAllergy/Immunology, Johns Hopkins University, USA.
Hans Jürgen HoffmanRespiratory Diseases, University of Aarhus, Denmark.
Jens M HohlfeldRespiratory Medicine, Hannover Medical School, Airway Research Fraunhofer Institute for Toxicology and Experimental Medicine, German Center for Lung Research, Germany.
Steven M HouserOtolaryngology, Case Western Reserve University, USA.
Peter H HwangOtolaryngology, Stanford University, USA.
Cristoforo IncorvaiaAllergy/Immunology, ASST Pini/CTO Milan, Italy.
Deborah JarvisPublic Health, Imperial College London, UK.
Ayesha N KhalidOtolaryngology, Harvard Medical School, USA.
Maritta KilpeläinenPulmonary/Allergy, Turku University Hospital, Finland.
Todd T KingdomOtolaryngology, University of Colorado, USA.
Helene KrouseNursing, University of Texas Rio Grande Valley, USA.
Desiree Larenas-LinnemannPediatric Allergy, Hospital Medica Sur, Mexico.
Adrienne M LauryOtolaryngology, San Antonio Military Medical Center, USA.
Stella E LeeOtolaryngology, University of Pittsburgh, USA.
Joshua M LevyOtolaryngology, Emory University, USA.
Amber U LuongOtolaryngology, McGovern Medical School at the University of Texas Health Science Center Houston, USA.
Bradley F MarpleOtolaryngology, University of Texas Southwestern, USA.
Edward D McCoulOtolaryngology, Ochsner Clinic Foundation, USA.
K Christopher McMainsOtolaryngology, Uniformed Services University of Health Sciences, USA.
Erik MelénPediatric Allergy, Karolinska Institutet, Sweden.
James W MimsOtolaryngology, Wake Forest University, USA.
Gianna MoscatoAllergy/Immunology, University of Pavia, Italy.
Joaquim MullolOtolaryngology, Universitat de Barcelona, Hospital Clinic, IDIBAPS, Spain.
Harold S NelsonAllergy/Immunology, National Jewish Health, USA.
Monica PatadiaOtolaryngology, Loyola University, USA.
Ruby PawankarPediatrics, Nippon Medical School, Japan.
Oliver PfaarRhinology/Allergy, Medical Faculty Mannheim, Heidelberg University,  Center for Rhinology and Allergology, Wiesbaden, Germany.
Michael P PlattOtolaryngology, Boston University, USA.
William ReisacherOtolaryngology, Weill Cornell Medical College, USA.
Carmen RondónAllergy, Regional University Hospital of Málaga, Spain.
Luke RudmikOtolaryngology, University of Calgary, Canada.
Matthew RyanOtolaryngology, University of Texas Southwestern, USA.
Joaquin SastreAllergology, Hospital Universitario Fundacion Jiminez Diaz, Spain.
Rodney J SchlosserOtolaryngology, Medical University of South Carolina, USA.
Russell A SettipaneAllergy/Immunology, Alpert Medical School of Brown University, USA.
Hemant P SharmaAllergy/Immunology, Children's National Health System, George Washington University School of Medicine, USA.
Aziz SheikhAllergy/Asthma, University of Edinburgh, UK.
Timothy L SmithOtolaryngology, Oregon Health and Science University, USA.
Pongsakorn TantilipikornRhinology/Allergy, Mahidol University, Thailand.
Jody R TverskyAllergy/Immunology, Johns Hopkins University, USA.
Maria C VelingOtolaryngology, University of Texas Southwestern, USA.
De Yun WangOtolaryngology, National University of Singapore, Singapore.
Marit WestmanOtolaryngology, Karolinska Institutet, Sweden.
Magnus WickmanEnvironmental Medicine, Karolinska Institutet, Sweden.
Mark ZacharekOtolaryngology, University of Michigan, USA.
Johns Hopkins University · USEmory University · USThe University of Texas Southwestern Medical Center · USKarolinska Institutet · SEImperial College London · GBUniversity of Chicago · USUniversity of Utah · USAarhus University · DKAsthma UK · GBBoston University · USBrooke Army Medical Center · USBrown University · USCase Western Reserve University · USChildren's National · USCornell University · USEskişehir Osmangazi University · TRFraunhofer Institute for Toxicology and Experimental Medicine · DEGhent University Hospital · BEHarvard University · USHelios Kliniken · DE

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Institutional Career Development CoreKL2TR002381 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Anandi Nayan Sheth · 2017 to 2026
$14.1M
University of Utah Center for clinical and Translational ScienceKL2TR001065 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$1.1M
NCATS NIH HHS KL2 TR001065NCATS NIH HHS KL2 TR002381NCATS NIH HHS UL1 TR002378
6 · The paper itself

Abstract

backgroundCritical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR).

methodsUsing previously described methodology, specific topics were developed relating to AR. Each topic was assigned a literature review, evidence-based review (EBR), or evidence-based review with recommendations (EBRR) format as dictated by available evidence and purpose within the ICAR:AR document. Following iterative reviews of each topic, the ICAR:AR document was synthesized and reviewed by all authors for consensus.

resultsThe ICAR:AR document addresses over 100 individual topics related to AR, including diagnosis, pathophysiology, epidemiology, disease burden, risk factors for the development of AR, allergy testing modalities, treatment, and other conditions/comorbidities associated with AR.

conclusionThis critical review of the AR literature has identified several strengths; providers can be confident that treatment decisions are supported by rigorous studies. However, there are also substantial gaps in the AR literature. These knowledge gaps should be viewed as opportunities for improvement, as often the things that we teach and the medicine that we practice are not based on the best quality evidence. This document aims to highlight the strengths and weaknesses of the AR literature to identify areas for future AR research and improved understanding.

Indexed as

Adrenal Cortex HormonesAllergensBiological ProductsComplementary TherapiesCytokinesDiagnosis, DifferentialDrug Therapy, CombinationEndoscopyEnvironmental ExposureEpidemiologic MethodsHistamine AntagonistsHumansImmunoglobulin EMicrobiotaNasal DecongestantsOccupational DiseasesAdrenal Cortex HormonesAllergensBiological ProductsCytokinesHistamine AntagonistsImmunoglobulin ENasal DecongestantsSaline Solutionallergen extractallergen immunotherapyallergic rhinitisallergyantihistamineasthmaatopic dermatitisavoidancebiologiccockroachconjunctivitisconsensuscorticosteroidcoughcromolyndecongestantenvironmenteosinophilic esophagitisepicutaneous immunotherapyepidemiologyevidence-based medicinefood allergygeneticshouse dust miteIgEimmunoglobulin Eimmunotherapyinhalant allergyleukotrienemicrobiomeoccupational rhinitisomalizumabpathophysiologyperennialpet danderpollenprobioticquality of liferhinitisrhinosinusitisrisk factorsalineseasonalsensitizationsinusitissleepsocioeconomicspecific IgEsubcutaneous immunotherapysublingual immunotherapysystematic reviewtotal IgEtranscutaneous immunotherapyvalidated survey

Identifiers

PMID29438602
PMCPMC7286723
OpenAlexW2793898214

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.