SynthesisSchizophrenia bulletin2018
Can We Predict Psychosis Outside the Clinical High-Risk State? A Systematic Review of Non-Psychotic Risk Syndromes for Mental Disorders.
Synthesis in Schizophrenia bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Neuropsychological Performance Among Individuals at Clinical High-Risk for Psychosis vs Putatively Low-Risk Peers With Other Psychopathology: A Systematic Review and Meta-Analysis.Schizophrenia bulletin · 2022Pooled it
- Value representation in youth psychopathology: evidence of a transdiagnostic risk mechanism for psychosis.Translational psychiatry · 2026Article
- Accelerating Access to Early Intervention Through Hospital-Wide Outreach and Enhanced Referral Support.Early intervention in psychiatry · 2026Article
- Do Obsessive-Compulsive Symptoms Increase the Risk of Developing Psychosis? A Systematic Review and Meta-analysis.Schizophrenia bulletin open · 2026Article
- Characterizing the Clinical Trajectory and Predicting Persistence and Deterioration of Attenuated Psychotic Symptoms in Ultra-High-Risk Individuals.Schizophrenia bulletin · 2025Article
- Quantitative semiology: harnessing AI-generated teaching signals in psychiatry.Journal of psychiatry & neuroscience : JPN · 2025Article
- Multimodal Prediction of Psychosis in the Prospective MoBa Birth Cohort.Research square · 2025Article
- Obstacles to Seeking Help: Perceived Barriers and Stigma Towards Mental Health Treatment in College Students at Elevated Risk for Psychosis.Early intervention in psychiatry · 2025Article
- Development and temporal validation of a clinical prediction model of transition to psychosis in individuals at ultra-high risk in the UHR 1000+ cohort.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis.Schizophrenia bulletin · 2024Article
- Psychosis superspectrum I: Nosology, etiology, and lifespan development.Molecular psychiatry · 2024Review
- Improving screening methods for psychosis in an adolescent help-seeking population using the Child Behavior Checklist (CBCL) and the Youth Self Report (YSR) versus the Prodromal Questionnaire -16 items version (PQ-16).Child and adolescent psychiatry and mental health · 2022Article
- Toward Generalizable and Transdiagnostic Tools for Psychosis Prediction: An Independent Validation and Improvement of the NAPLS-2 Risk Calculator in the Multisite PRONIA Cohort.Biological psychiatry · 2021Article
- MicroRNAs in the Onset of Schizophrenia.Cells · 2021Review
- Psychiatric risk and resilience: Plasticity genes and positive mental health.Brain and behavior · 2021Article
- First episode psychosis: register-based study of comorbid psychiatric disorders and medications before and after.European archives of psychiatry and clinical neuroscience · 2021Observational
- Genetic and clinical analyses of psychosis spectrum symptoms in a large multiethnic youth cohort reveal significant link with ADHD.Translational psychiatry · 2021Article
- The Relationship between PID-5 Personality Traits and Mental States. A Study on a Group of Young Adults at Risk of Psychotic Onset.Medicina (Kaunas, Lithuania) · 2021Article
- Real-world implementation of precision psychiatry: Transdiagnostic risk calculator for the automatic detection of individuals at-risk of psychosis.Schizophrenia research · 2021Article
- Transcending false dichotomies and diagnostic silos to reduce disease burden in mental disorders.Social psychiatry and psychiatric epidemiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence has suggested that psychosis could develop not only in people at clinical high risk for psychosis (CHR-P) but also in those with clinical risk syndromes for emergent nonpsychotic mental disorders. The proportion of people with these clinical risk syndromes who will develop psychosis rather than to other nonpsychotic mental disorders is undetermined. Electronic databases were searched for studies reporting on clinical risk syndromes for the development of emergent nonpsychotic mental disorders. Incidence of emerging psychotic and nonpsychotic mental disorders defined on the ICD or DSM. Of a total of 9 studies relating to 3006 nonpsychotic at-risk individuals were included. Within prospective studies (n = 4, sample = 1051), the pooled incidence of new psychotic disorders across these clinical risk syndromes was of 12.9 per 1000 person-years (95% CI: 4.3 to 38.6) and that of nonpsychotic disorders (n = 3, sample = 538) was of 43.5 per 1000 person-years (95% CI: 30.9 to 61.3). Psychotic disorders may emerge outside the CHR-P paradigm, from clinical risk syndromes for incident nonpsychotic disorders, albeit at lower rates than in the CHR-P group. The clinical risk syndromes for emerging nonpsychotic disorders may exhibit a pluripotential risk of developing several types of mental disorders compared with CHR-P. If substantiated by future research, the current findings suggest that it may be useful to move beyond the current strategy of identifying individuals meeting CHR-P criteria only.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.