Evidence map›Paper›PMID 29438558›Full record

ArticleBioinformatics (Oxford, England)2018

KMgene: a unified R package for gene-based association analysis for complex traits.

Qi Yan, Zhou Fang, Wei Chen

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Qi YanDivision of Pulmonary Medicine, Allergy and Immunology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA.
Zhou FangDepartment of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Wei ChenDivision of Pulmonary Medicine, Allergy and Immunology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Statistical methods for population and family-based whole-genome sequence dataR01HG007358 · NHGRI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, WEI · 2014 to 2018
$1.7M
AMD genetics: methods and analysis for progression, prediction, and associationR01EY024226 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHEN, WEI · 2014 to 2016
$899k
NEI NIH HHS R01 EY024226NHGRI NIH HHS R01 HG007358
6 · The paper itself

Abstract

Summary: In this report, we introduce an R package KMgene for performing gene-based association tests for familial, multivariate or longitudinal traits using kernel machine (KM) regression under a generalized linear mixed model framework. Extensive simulations were performed to evaluate the validity of the approaches implemented in KMgene. Availability and implementation: http://cran.r-project.org/web/packages/KMgene. Supplementary information: Supplementary data are available at Bioinformatics online.

Indexed as

Linear ModelsMultifactorial InheritanceSoftwareGenetic TestingHumansLungModels, Genetic

Identifiers

PMID29438558
PMCPMC6246171

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.