ArticlePloS one2018
Longitudinal changes in telomere length and associated genetic parameters in dairy cattle analysed using random regression models.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Effects of the Prenatal Maternal Health Status on Calf Disease Prevalences and Respective Genetic Parameter Estimates in German Holstein Cattle.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2025Article
- Heritability and age-dependent changes in genetic variation of telomere length in a wild house sparrow population.Evolution letters · 2025Article
- Shortening of the telomere length during the transition period of dairy cows in relation to biological stress.Scientific reports · 2024Article
- Telomere Dynamics in Livestock.Biology · 2023Review
- Article
- Comparison of Telomere Length in Age-Matched Primiparous and Multiparous Brahman Cows.Animals : an open access journal from MDPI · 2023Article
- Characterization of telomere length in Agerolese cattle breed, correlating blood and milk samples.Animal genetics · 2022Article
- Heritable variation in telomere length predicts mortality in Soay sheep.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Telomere attrition rates are associated with weather conditions and predict productive lifespan in dairy cattle.Scientific reports · 2021Article
- Seasonal variation in telomere dynamics in African striped mice.Oecologia · 2020Article
- The Genetic Architecture of Bovine Telomere Length in Early Life and Association With Animal Fitness.Frontiers in genetics · 2019Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Telomeres cap the ends of linear chromosomes and shorten with age in many organisms. In humans short telomeres have been linked to morbidity and mortality. With the accumulation of longitudinal datasets the focus shifts from investigating telomere length (TL) to exploring TL change within individuals over time. Some studies indicate that the speed of telomere attrition is predictive of future disease. The objectives of the present study were to 1) characterize the change in bovine relative leukocyte TL (RLTL) across the lifetime in Holstein Friesian dairy cattle, 2) estimate genetic parameters of RLTL over time and 3) investigate the association of differences in individual RLTL profiles with productive lifespan. RLTL measurements were analysed using Legendre polynomials in a random regression model to describe TL profiles and genetic variance over age. The analyses were based on 1,328 repeated RLTL measurements of 308 female Holstein Friesian dairy cattle. A quadratic Legendre polynomial was fitted to the fixed effect of age in months and to the random effect of the animal identity. Changes in RLTL, heritability and within-trait genetic correlation along the age trajectory were calculated and illustrated. At a population level, the relationship between RLTL and age was described by a positive quadratic function. Individuals varied significantly regarding the direction and amount of RLTL change over life. The heritability of RLTL ranged from 0.36 to 0.47 (SE = 0.05-0.08) and remained statistically unchanged over time. The genetic correlation of RLTL at birth with measurements later in life decreased with the time interval between samplings from near unity to 0.69, indicating that TL later in life might be regulated by different genes than TL early in life. Even though animals differed in their RLTL profiles significantly, those differences were not correlated with productive lifespan (p = 0.954).
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