Evidence map›Paper›PMID 29438368›Full record

ArticleBritish journal of cancer2018

Clinical outcome of concomitant vs interrupted BRAF inhibitor therapy during radiotherapy in melanoma patients.

Markus Hecht, Friedegund Meier, Lisa Zimmer, Bülent Polat, Carmen Loquai, Carsten Weishaupt, Andrea Forschner, Ralf Gutzmer, Jochen S Utikal, Simone M Goldinger and 15 more

Abstract readMulticenter Study
In one paragraph

Article in British journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Integrated approaches to sensitizing melanoma to radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Review
  3. Review
  4. Tumor-specific radiosensitizing effect of the ATM inhibitor AZD0156 in melanoma cells with low toxicity to healthy fibroblasts.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2023
    Article
  5. Article
  6. Article
  7. Review
  8. Kinase inhibitors increase individual radiation sensitivity in normal cells of cancer patients.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2022
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Current Treatment of Melanoma Brain Metastasis.Current treatment options in oncology · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Markus HechtDepartment of Radiation Oncology, University Hospital Erlangen, Erlangen, Germany.
Friedegund MeierDepartment of Dermatology, University Hospital Dresden, Dresden, Germany.
Lisa ZimmerDepartment of Dermatology, University Hospital Essen, Essen, Germany.
Bülent PolatDepartment of Radiation Oncology, University Hospital Würzburg, Würzburg, Germany.
Carmen LoquaiDepartment of Dermatology, University Medical Center Mainz, Mainz, Germany.
Carsten WeishauptDepartment of Dermatology, University Hospital Münster, Münster, Germany.
Andrea ForschnerDepartment of Dermatology, University Hospital Tübingen, Tübingen, Germany.
Ralf GutzmerSkin Cancer Center Hannover, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Jochen S UtikalSkin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Simone M GoldingerDepartment of Dermatology, University Hospital Zürich, Zürich, Switzerland.
Michael GeierDepartment of Radiation Oncology, Ordensklinikum Linz, Linz, Austria.
Jessica C HasselDepartment of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.
Panagiotis BalermpasDepartment of Radiation Oncology, University Hospital Frankfurt, Frankfurt, Germany.
Felix KieckerDepartment of Dermatology, University Hospital Berlin, Berlin, Germany.
Ricarda RauschenbergDepartment of Dermatology, University Hospital Dresden, Dresden, Germany.
Ursula DietrichDepartment of Dermatology, University Hospital Dresden, Dresden, Germany.
Patrick ClemensDepartment of Radiation Oncology, Hospital Feldkirch, Feldkirch, Austria.
Carola BerkingDepartment of Dermatology, University Hospital LMU Munich, München, Germany.
Gerhard GrabenbauerDepartment of Radiation Oncology, Hospital Coburg, Coburg, Germany.
Dirk SchadendorfDepartment of Dermatology, University Hospital Essen, Essen, Germany.
Stephan GrabbeDepartment of Dermatology, University Medical Center Mainz, Mainz, Germany.
Gerold SchulerDepartment of Dermatology, University Hospital Erlangen, Erlangen, Germany.
Rainer FietkauDepartment of Radiation Oncology, University Hospital Erlangen, Erlangen, Germany.
Luitpold V DistelDepartment of Radiation Oncology, University Hospital Erlangen, Erlangen, Germany.
Lucie HeinzerlingDepartment of Dermatology, University Hospital Erlangen, Erlangen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This corrects the article DOI: 10.1038/bjc.2017.85.

Indexed as

AdolescentAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsCohort StudiesDrug Administration ScheduleFemaleHumansImidazolesMaleMelanomaMiddle AgedOximesProtein Kinase InhibitorsProto-Oncogene Proteins B-rafBRAF protein, humandabrafenibImidazolesOximesProtein Kinase InhibitorsProto-Oncogene Proteins B-rafRadiation-Sensitizing AgentsVemurafenib

Identifiers

PMID29438368
PMCPMC5886123

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.