ArticlePain2018
Traits associated with central pain augmentation in the Knee Pain In the Community (KPIC) cohort.
Article in Pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Magnetic Therapy on Pain Relief in Postoperation Patients
Molecular Pathways Involved in Knee Pain: an Observational Study
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Pooled it
- High Prevalence of Pain Sensitization in Knee Osteoarthritis: A Meta-Analysis with Meta-Regression.CartilagePooled it
- Observational
- Validity and contributions to pain from the central aspects of pain questionnaire in rheumatoid arthritis.Pain reports · 2025Article
- Central aspects of pain associated with physical activity: results from the Investigating Musculoskeletal Health and Wellbeing cohort.Pain reports · 2025Article
- The importance of central sensitization for clinical trials of disease modifying osteoarthritis drugs (DMOADs).Osteoarthritis imaging · 2025Article
- Osteoarthritis.Nature reviews. Disease primers · 2025Review
- Sleep disturbance and multimorbidity: a cross-sectional and longitudinal study in the knee pain and related health in the community cohort.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Evolution and characteristics of nocturnal knee pain after knee arthroplasty.Archives of orthopaedic and trauma surgery · 2024Observational
- Limited content overlap between commonly used self-report instruments for central (pain) sensitization in rheumatology.Rheumatology advances in practice · 2024Article
- Health equity profile of knee replacement patients in the South African public sector: A descriptive study.The South African journal of physiotherapy · 2024Article
- Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study.Osteoarthritis and cartilage open · 2023Article
- Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort.Journal of personalized medicine · 2023Article
- Comparison of the effects of transcutaneous electrical nerve stimulation and interferential current therapies in central sensitization in patients with knee osteoarthritis.The Korean journal of pain · 2023Article
- How people with knee pain understand why their pain changes or remains the same over time: A qualitative study.Osteoarthritis and cartilage open · 2023Article
- Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network.Rheumatology (Oxford, England) · 2022Article
- The association of socio-economic and psychological factors with limitations in day-to-day activity over 7 years in newly diagnosed osteoarthritis patients.Scientific reports · 2022Article
- Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study.BMC rheumatology · 2021Article
- The Central Aspects of Pain in the Knee (CAP-Knee) questionnaire; a mixed-methods study of a self-report instrument for assessing central mechanisms in people with knee pain.Osteoarthritis and cartilage · 2021Observational
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
This study aimed to identify self-report correlates of central pain augmentation in individuals with knee pain. A subset of participants (n = 420) in the Knee Pain and related health In the Community (KPIC) baseline survey undertook pressure pain detection threshold (PPT) assessments. Items measuring specific traits related to central pain mechanisms were selected from the survey based on expert consensus, face validity, item association with underlying constructs measured by originating host questionnaires, adequate targeting, and PPT correlations. Pain distribution was reported on a body manikin. A "central pain mechanisms" factor was sought by factor analysis. Associations of items, the derived factor, and originating questionnaires with PPTs were compared. Eight self-report items measuring traits of anxiety, depression, catastrophizing, neuropathic-like pain, fatigue, sleep disturbance, pain distribution, and cognitive impact were identified as likely indices of central pain mechanisms. Pressure pain detection thresholds were associated with items representing each trait and with their originating scales. Pain distribution classified as "pain below the waist additional to knee pain" was more strongly associated with low PPT than were alternative classifications of pain distribution. A single factor, interpreted as "central pain mechanisms," was identified across the 8 selected items and explained variation in PPT (R = 0.17) better than did any originating scale (R = 0.10-0.13). In conclusion, including representative items within a composite self-report tool might help identify people with centrally augmented knee pain.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.