ArticleProceedings of the National Academy of Sciences of the United States of America2018
Temporal-prefrontal cortical network for discrimination of valuable objects in long-term memory.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Multiple groups of neurons in the superior colliculus convert value signals into saccadic vigor.iScience · 2026Article
- Prefrontal cortex temporally multiplexes slow and fast dynamics in value learning and memory.Nature communications · 2025Article
- The Orbitofrontal Cortex Underlies Consolidation of Pavlovian Anticipatory Arousal Responses in Macaque Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Brain areas for reversible symbolic reference, a potential singularity of the human brain.eLife · 2025Article
- Potential common targets of music therapy intervention in neuropsychiatric disorders: the prefrontal cortex-hippocampus -amygdala circuit (a review).Frontiers in human neuroscience · 2025Review
- Implication of regional selectivity of dopamine deficits in impaired suppressing of involuntary movements in Parkinson's disease.Neuroscience and biobehavioral reviews · 2024Review
- Article
- Robust memory of face moral values is encoded in the human caudate tail: a simultaneous EEG-fMRI study.Scientific reports · 2024Article
- Functional connectivity of the amygdala subregions and the antidepressant effects of repeated ketamine infusions in major depressive disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Curiosity: primate neural circuits for novelty and information seeking.Nature reviews. Neuroscience · 2024Review
- Value-Based Search Efficiency Is Encoded in the Substantia Nigra Reticulata Firing Rate, Spiking Irregularity and Local Field Potential.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Prefrontal cortex encodes value pop-out in visual search.iScience · 2023Article
- Structured memory representations develop at multiple time scales in hippocampal-cortical networks.bioRxiv : the preprint server for biology · 2023Article
- The cognitive dysfunction of claustrum on Alzheimer's disease: A mini-review.Frontiers in aging neuroscience · 2023Review
- Article
- Limited Pairings of Electrical Micro-stimulation of the Ventral Tegmental Area and a Visual Stimulus Enhance Visual Cortical Responses.Journal of cognitive neuroscience · 2022Article
- Prefrontal cortex interactions with the amygdala in primates.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Ultrasound modulation of macaque prefrontal cortex selectively alters credit assignment-related activity and behavior.Science advances · 2021Article
- Brain substrates for automatic retrieval of value memory in the primate basal ganglia.Molecular brain · 2021Review
- Common coding of expected value and value uncertainty memories in the prefrontal cortex and basal ganglia output.Science advances · 2021Article
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4 authors.
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Abstract
Remembering and discriminating objects based on their previously learned values are essential for goal-directed behaviors. While the cerebral cortex is known to contribute to object recognition, surprisingly little is known about its role in retaining long-term object-value associations. To address this question, we trained macaques to arbitrarily associate small or large rewards with many random fractal objects (>100) and then used fMRI to study the long-term retention of value-based response selectivity across the brain. We found a pronounced long-term value memory in core subregions of temporal and prefrontal cortex where, several months after training, fractals previously associated with high reward ("good" stimuli) elicited elevated fMRI responses compared with those associated with low reward ("bad" stimuli). Similar long-term value-based modulation was also observed in subregions of the striatum, amygdala, and claustrum, but not in the hippocampus. The value-modulated temporal-prefrontal subregions showed strong resting-state functional connectivity to each other. Moreover, for areas outside this core, the magnitude of long-term value responses was predicted by the strength of resting-state functional connectivity to the core subregions. In separate testing, free-viewing gaze behavior indicated that the monkeys retained stable long-term memory of object value. These results suggest an implicit and high-capacity memory mechanism in the temporal-prefrontal circuitry and its associated subcortical regions for long-term retention of object-value memories that can guide value-oriented behavior.
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