Evidence map›Paper›PMID 29437971›Full record

ArticleJournal of virology2018

N-Terminomics TAILS Identifies Host Cell Substrates of Poliovirus and Coxsackievirus B3 3C Proteinases That Modulate Virus Infection.

Julienne M Jagdeo, Antoine Dufour, Theo Klein, Nestor Solis, Oded Kleifeld, Jayachandran Kizhakkedathu, Honglin Luo, Christopher M Overall, Eric Jan

Abstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

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  13. Integrating the analysis of human biopsies using post-translational modifications proteomics.Protein science : a publication of the Protein Society · 2024
    Review
  14. Article
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  20. The Mechanism of Resistance of EUROPEAN Plum toPlants (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Julienne M JagdeoDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Antoine DufourLife Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Theo KleinLife Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Nestor SolisLife Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Oded KleifeldSchool of Biomedical Sciences, Monash University, Victoria, Australia.
Jayachandran KizhakkedathuDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Honglin LuoDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Christopher M OverallDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.
Eric JanDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada ej@mail.ubc.ca.ORCID https://orcid.org/0000-0003-0523-8467

Funding

Canadian Institutes of Health Research MOP-37937Canadian Institutes of Health Research MOP-81244
6 · The paper itself

Abstract

Enteroviruses encode proteinases that are essential for processing of the translated viral polyprotein. In addition, viral proteinases also target host proteins to manipulate cellular processes and evade innate antiviral responses to promote replication and infection. Although some host protein substrates of enterovirus proteinases have been identified, the full repertoire of targets remains unknown. We used a novel quantitative

Indexed as

3C Viral ProteasesCarbon-Nitrogen Ligases with Glutamine as Amide-N-DonorCysteine EndopeptidasesEnterovirus B, HumanHeLa CellsHeterogeneous-Nuclear Ribonucleoprotein KHumansIsotope LabelingPoliovirusSubstrate SpecificityViral Proteins3C Viral ProteasesCarbon-Nitrogen Ligases with Glutamine as Amide-N-DonorCysteine EndopeptidasesHeterogeneous-Nuclear Ribonucleoprotein Kphosphoribosylformylglycinamidine synthetaseViral Proteinscoxsackievirusenterovirusplus-strand RNA viruspoliovirusproteasesproteinaseproteomicsRNA replication

Identifiers

PMID29437971
PMCPMC5874412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.