Evidence map›Paper›PMID 29437963›Full record

ArticleJournal of virology2018

Induction of Genotype Cross-Reactive, Hepatitis C Virus-Specific, Cell-Mediated Immunity in DNA-Vaccinated Mice.

Danushka K Wijesundara, Jason Gummow, Yanrui Li, Wenbo Yu, Benjamin J Quah, Charani Ranasinghe, Joseph Torresi, Eric J Gowans, Branka Grubor-Bauk

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Danushka K Wijesundara *Discipline of Surgery, Basil Hetzel Institute, University of Adelaide, Woodville South, South Australia, Australia.
Jason Gummow *Discipline of Surgery, Basil Hetzel Institute, University of Adelaide, Woodville South, South Australia, Australia.
Yanrui LiDiscipline of Surgery, Basil Hetzel Institute, University of Adelaide, Woodville South, South Australia, Australia.
Wenbo YuDiscipline of Surgery, Basil Hetzel Institute, University of Adelaide, Woodville South, South Australia, Australia.
Benjamin J QuahCancer and Vascular Biology Group, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Charani RanasingheMolecular Mucosal Vaccine Immunology Group, The John Curtin School of Medical Research, The Australian National University, Canberra, Australia.
Joseph TorresiDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia.
Eric J Gowans *Discipline of Surgery, Basil Hetzel Institute, University of Adelaide, Woodville South, South Australia, Australia eric.gowans@adelaide.edu.au.
Branka Grubor-Bauk *Discipline of Surgery, Basil Hetzel Institute, University of Adelaide, Woodville South, South Australia, Australia.
University of Adelaide · AUAustralian National University · AUBasil Hetzel Institute · AUPeter Doherty Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A universal hepatitis C virus (HCV) vaccine should elicit multiantigenic, multigenotypic responses, which are more likely to protect against challenge with the range of genotypes and subtypes circulating in the community. A vaccine cocktail and vaccines encoding consensus HCV sequences are attractive approaches to achieve this goal. Consequently, in a series of mouse vaccination studies, we compared the immunogenicity of a DNA vaccine encoding a consensus HCV nonstructural 5B (NS5B) protein to that of a cocktail of DNA plasmids encoding the genotype 1b (Gt1b) and Gt3a NS5B proteins. To complement this study, we assessed responses to a multiantigenic cocktail regimen by comparing a DNA vaccine cocktail encoding Gt1b and Gt3a NS3, NS4, and NS5B proteins to a single-genotype NS3/4/5B DNA vaccine. To thoroughly evaluate

Indexed as

GenotypeImmunity, CellularAnimalsCross ReactionsFemaleHEK293 CellsHepacivirusHepatitis CHumansMiceMice, Inbred BALB CRNA-Dependent RNA PolymeraseT-LymphocytesVaccines, DNAViral Hepatitis VaccinesViral Nonstructural ProteinsNS-5 protein, hepatitis C virusRNA-Dependent RNA PolymeraseVaccines, DNAViral Hepatitis VaccinesViral Nonstructural ProteinsconsensusDNA vaccinesELISpotHCVhepatitismultiantigenicmultigenotypicNS5vaccine

Identifiers

PMID29437963
PMCPMC5874410
OpenAlexW2792164894

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.