Evidence map›Paper›PMID 29437959›Full record

ArticleJournal of virology2018

The Unstructured Paramyxovirus Nucleocapsid Protein Tail Domain Modulates Viral Pathogenesis through Regulation of Transcriptase Activity.

Vidhi D Thakkar, Robert M Cox, Bevan Sawatsky, Renata da Fontoura Budaszewski, Julien Sourimant, Katrin Wabbel, Negar Makhsous, Alexander L Greninger, Veronika von Messling, Richard K Plemper

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

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  15. Modulation of Measles Virus NBiomolecules · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Vidhi D Thakkar *Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA.
Robert M Cox *Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA.
Bevan SawatskyVeterinary Medicine Division, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen, Germany.
Renata da Fontoura BudaszewskiVeterinary Medicine Division, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen, Germany.
Julien SourimantInstitute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA.
Katrin WabbelInstitute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA.
Negar MakhsousVirology Division, Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Alexander L GreningerVirology Division, Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Veronika von MesslingVeterinary Medicine Division, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen, Germany.ORCID https://orcid.org/0000-0002-3972-8723
Richard K PlemperInstitute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA rplemper@gsu.edu.
Georgia State University · USPaul Ehrlich Institut · DEUniversity of Washington · USUniversidade Federal do Rio Grande do Sul · BR

Funding

Identification and Pre-Clinical Evaluation of Measles Virus InhibitorsR01AI071002 · NIAID · GEORGIA STATE UNIVERSITY · PI PLEMPER, RICHARD K. · 2006 to 2022
$6.6M
Novel Therapeutics against Respiratory Syncytial Virus InfectionR01HD079327 · NICHD · GEORGIA STATE UNIVERSITY · PI PLEMPER, RICHARD K. · 2014 to 2018
$2.8M
NIAID NIH HHS R01 AI071002NICHD NIH HHS R01 HD079327
6 · The paper itself

Abstract

The paramyxovirus replication machinery comprises the viral large (L) protein and phosphoprotein (P-protein) in addition to the nucleocapsid (N) protein, which encapsidates the single-stranded RNA genome. Common to paramyxovirus N proteins is a C-terminal tail (Ntail). The mechanistic role and relevance for virus replication of the structurally disordered central Ntail section are unknown. Focusing initially on members of the

Indexed as

AnimalsChlorocebus aethiopsCricetinaeDisease Models, AnimalDistemper Virus, CanineFerretsHeLa CellsHumansMeaslesMeasles virusNucleocapsid ProteinsProtein DomainsVirus ReplicationNucleocapsid Proteinsmeasles virusnucleocapsid proteinparamyxovirusRdRp complexviral pathogenesisvirus replication

Identifiers

PMID29437959
PMCPMC5874420
OpenAlexW2791523766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.