ArticleProceedings of the National Academy of Sciences of the United States of America2018
Septal cholinergic neurons gate hippocampal output to entorhinal cortex via oriens lacunosum moleculare interneurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Acetylcholine: a candidate substrate for hippocampal predictive learning?Nature reviews. Neuroscience · 2026Review
- Voltage imaging of CA1 pyramidal cells and SST+ interneurons reveals stability and plasticity mechanisms of spatial firing.Nature communications · 2026Article
- vCA1 SST neurons represent avoidance states that guide anxiety-related behavioral choices.bioRxiv : the preprint server for biology · 2026Article
- Hippocampal OLM interneurons regulate CA1 place cell plasticity and remapping.Nature communications · 2025Article
- Differentiated Presynaptic Input to OLMɑ2 Cells Along the Hippocampal Dorsoventral Axis: Implications for Hippocampal Microcircuit Function.Hippocampus · 2025Article
- Distinct Electrophysiological Signatures Define Neuronal Subtypes in the Fasciola Cinereum.bioRxiv : the preprint server for biology · 2025Article
- Atypical hippocampal excitatory neurons express and govern object memory.Nature communications · 2025Article
- Navigating uncertainty: reward location variability induces reorganization of hippocampal spatial representations.bioRxiv : the preprint server for biology · 2025Article
- Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons.PLoS biology · 2024Article
- Entorhinal cortex-hippocampal circuit connectivity in health and disease.Frontiers in human neuroscience · 2024Review
- Activation of medial septum cholinergic neurons restores cognitive function in temporal lobe epilepsy.Neural regeneration research · 2023Article
- ACh Transfers: Homeostatic Plasticity of Cholinergic Synapses.Cellular and molecular neurobiology · 2023Review
- Selective Menin Deletion in the Hippocampal CA1 Region Leads to Disruption of Contextual Memory in theCells · 2022Article
- Neuronal circuitry for recognition memory of object and place in rodent models.Neuroscience and biobehavioral reviews · 2022Review
- The role of inhibitory circuits in hippocampal memory processing.Nature reviews. Neuroscience · 2022Review
- Cholinergic Regulation of Hippocampal Theta Rhythm.Biomedicines · 2022Review
- α7 nicotinic acetylcholine receptors in the hippocampal circuit: taming complexity.Trends in neurosciences · 2022Review
- Loss of GABA co-transmission from cholinergic neurons impairs behaviors related to hippocampal, striatal, and medial prefrontal cortex functions.Frontiers in behavioral neuroscience · 2022Article
- mGluCell reports · 2021Article
- Central Cholinergic Synapse Formation in Optimized Primary Septal-Hippocampal Co-cultures.Cellular and molecular neurobiology · 2021Article
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4 authors.
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Abstract
Neuromodulation of neural networks, whereby a selected circuit is regulated by a particular modulator, plays a critical role in learning and memory. Among neuromodulators, acetylcholine (ACh) plays a critical role in hippocampus-dependent memory and has been shown to modulate neuronal circuits in the hippocampus. However, it has remained unknown how ACh modulates hippocampal output. Here, using in vitro and in vivo approaches, we show that ACh, by activating oriens lacunosum moleculare (OLM) interneurons and therefore augmenting the negative-feedback regulation to the CA1 pyramidal neurons, suppresses the circuit from the hippocampal area CA1 to the deep-layer entorhinal cortex (EC). We also demonstrate, using mouse behavior studies, that the ablation of OLM interneurons specifically impairs hippocampus-dependent but not hippocampus-independent learning. These data suggest that ACh plays an important role in regulating hippocampal output to the EC by activating OLM interneurons, which is critical for the formation of hippocampus-dependent memory.
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