ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Ketamine Alters Lateral Prefrontal Oscillations in a Rule-Based Working Memory Task.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Working Memory as a Candidate Mechanism Linking Aging and the Sense of Agency: A Narrative Review.Brain sciences · 2026Review
- Effects of Ketamine on Frontoparietal Interactions in a Rule-Based Antisaccade Task in Macaque Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Large-scale coupling of prefrontal activity patterns as a mechanism for cognitive control in health and disease: evidence from rodent models.Frontiers in neural circuits · 2024Review
- Enhanced low-gamma band power in the hippocampus and prefrontal cortex in a rat model of depression is reversed by orexin-1 receptor antagonism.IBRO neuroscience reports · 2023Article
- Article
- Using Nonhuman Primate Models to Reverse-Engineer Prefrontal Circuit Failure Underlying Cognitive Deficits in Schizophrenia.Current topics in behavioral neurosciences · 2023Review
- The NMDA receptor antagonist ketamine impairs and delays context-dependent decision making in the parietal cortex.Communications biology · 2022Article
- Shape and Rule Information Is Reflected in Different Local Field Potential Frequencies and Different Areas of the Primate Lateral Prefrontal Cortex.Frontiers in behavioral neuroscience · 2022Article
- Dependence of Working Memory on Coordinated Activity Across Brain Areas.Frontiers in systems neuroscience · 2021Review
- Assessment of brain cholesterol metabolism biomarker 24S-hydroxycholesterol in schizophrenia.NPJ schizophrenia · 2020Article
- Article
- Ketamine normalizes high-gamma power in the anterior cingulate cortex in a rat chronic pain model.Molecular brain · 2020Article
- Cognitive Control Errors in Nonhuman Primates Resembling Those in Schizophrenia Reflect Opposing Effects of NMDA Receptor Blockade on Causal Interactions Between Cells and Circuits in Prefrontal and Parietal Cortices.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Effects of Ketamine Administration on Auditory Information Processing in the Neocortex of Nonhuman Primates.Frontiers in psychiatry · 2020Article
- Macaque anterior cingulate cortex deactivation impairs performance and alters lateral prefrontal oscillatory activities in a rule-switching task.PLoS biology · 2019Article
- Modeling Schizophrenia's Abnormal Cortical Neural Synchrony in Monkeys.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Working Memory: Delay Activity, Yes! Persistent Activity? Maybe Not.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Ketamine-Induced Alteration of Working Memory Utility during Oculomotor Foraging Task in Monkeys.eNeuroArticle
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Authors and funding
4 authors at 4 institutions in 4 countries.
Funding
Abstract
Acute administration of N-methyl-D-aspartate receptor (NMDAR) antagonists in healthy humans and animals produces working memory deficits similar to those observed in schizophrenia. However, it is unclear whether they also lead to altered low-frequency (≤60 Hz) neural oscillatory activities similar to those associated with schizophrenia during working memory processes. Here, we recorded local field potentials (LFPs) and single-unit activity from the lateral prefrontal cortex (LPFC) of three male rhesus macaque monkeys while they performed a rule-based prosaccade and antisaccade working memory task both before and after systemic injections of a subanesthetic dose (≤0.7 mg/kg) of ketamine. Accompanying working-memory impairment, ketamine enhanced the low-gamma-band (30-60 Hz) and dampened the beta-band (13-30 Hz) oscillatory activities in the LPFC during both delay periods and intertrial intervals. It also increased task-related alpha-band activities, likely reflecting compromised attention. Beta-band oscillations may be especially relevant to working memory processes because stronger beta power weakly but significantly predicted shorter saccadic reaction time. Also in beta band, ketamine reduced the performance-related oscillation as well as the rule information encoded in the spectral power. Ketamine also reduced rule information in the spike field phase consistency in almost all frequencies up to 60 Hz. Our findings support NMDAR antagonists in nonhuman primates as a meaningful model for altered neural oscillations and synchrony, which reflect a disorganized network underlying the working memory deficits in schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.